人类MutL同源物1的启动子甲基化与结直肠癌风险：一项荟萃分析。

Promoter methylation of human mutL homolog 1 and colorectal cancer risk: A meta-analysis.

作者信息

Shi Bian, Chu Junfeng, Gao Qilong, Tian Tongde

机构信息

Combine Traditional Chinese and Western Medicine of Oncology, Henan Tumor Hospital, Zhengzhou 450008, Henan, China.

Department of Oncology, Henan Tumor Hospital, Zhengzhou 450008, Henan, China.

出版信息

J Cancer Res Ther. 2018;14(4):851-855. doi: 10.4103/0973-1482.172587.

DOI:10.4103/0973-1482.172587

PMID:29970664

Abstract

AIMS

Several studies suggested that promoter methylation of human mutL homolog 1 (hMLH1) was associated with the risk of colorectal cancer (CRC). However, other studies did not indicate the same results. To derive a more comprehensive estimation of the association between hMLH1 methylation and CRC risk, we conducted a meta-analysis.

MATERIALS AND METHODS

We searched in the PubMed, EMBASE, and WanFang Medicine databases. The strength of the associations was measured by odds ratios (ORs) with 95% confidence intervals (CIs).

RESULTS

A total of 47 studies with 4296 cases and 2827 controls were included. A statistically significant association between hMLH1 methylation and CRC risk was found (OR = 9.25; 95% CI, 5.65-15.53; P < 0.001). The heterogeneity was significant (P < 0.001). In the subgroup analysis of race, Asian and Caucasian with hMLH1 methylation had increased CRC risk (OR = 12.19; 95% CI, 7.02-23.42; P < 0.001 and OR = 6.38; 95% CI, 2.17-19.64; P < 0.001). In the subgroup analysis of sample source, only the sample from tissue showed increased CRC risk (OR = 10.46; 95% CI, 6.12-17.90; P < 0.001). The Egger's test did not find publication bias (P = 0.176).

CONCLUSIONS

In conclusion, this meta-analysis suggested that hMLH1 methylation was associated with an increased CRC risk.

摘要

目的

多项研究表明，人类错配修复蛋白1（hMLH1）启动子甲基化与结直肠癌（CRC）风险相关。然而，其他研究并未得出相同结果。为了更全面地评估hMLH1甲基化与CRC风险之间的关联，我们进行了一项荟萃分析。

材料与方法

我们检索了PubMed数据库、EMBASE数据库和万方医学数据库。采用优势比（OR）及95%置信区间（CI）来衡量关联强度。

结果

共纳入47项研究，涉及4296例病例和2827例对照。发现hMLH1甲基化与CRC风险之间存在统计学显著关联（OR = 9.25；95% CI，5.65 - 15.53；P < 0.001）。异质性显著（P < 0.001）。在种族亚组分析中，hMLH1甲基化的亚洲人和白种人患CRC的风险增加（OR = 12.19；95% CI，7.02 - 23.42；P < 0.001和OR = 6.38；95% CI，2.17 - 19.64；P < 0.001）。在样本来源亚组分析中，仅组织样本显示患CRC风险增加（OR = 10.46；95% CI，6.12 - 17.90；P < 0.001）。Egger检验未发现发表偏倚（P = 0.176）。