Tu Wen-Yong, Zhang Zhi-Yuan, Jun Zeng, Xu Xuan-Li, Ding Ji-Ping, Su Ji-Hui, Chen Zi-Mu
Department of Oral and Maxillofacial-Head and Neck Oncology, Division of Radiation Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Radiation Oncology, Wuxi Yiren Tumor Hospital, Jiangsu, China.
J Cancer Res Ther. 2018 Jun;14(Supplement):S416-S420. doi: 10.4103/0973-1482.179081.
The present study was designed to investigate the application of positron images from photonuclear reactions to verify the location of targeted radiation in vivo.
The phantom study was conducted with distilled water, porcine muscle, porcine adipose tissue, and graphite; these subjects were irradiated separately with 50 MV photons generated by an MM50 Racetrack Microtron. The positron emission activity was measured using a Geiger counter, and the radioactive decay curves for each of the irradiated materials were then established. The positron emission tomography (PET) images of the three tissue models were also achieved using the same radiation conditions. The in vivo PET imaging study was also conducted in tumor-bearing rabbits.
Our results demonstrated that the PET imaging could be used to verify the position of the irradiation field in vivo. The dose distribution images of photonuclear reactions of C and O were uniform, using 2-Gy 50 MV photons.
The factors influencing the half-life of radiation activity in various tissues were different from the first order kinetic reaction in physics.
本研究旨在探讨光核反应产生的正电子图像在体内验证靶向辐射位置的应用。
使用蒸馏水、猪肌肉、猪脂肪组织和石墨进行体模研究；这些样本分别用MM50跑道式电子回旋加速器产生的50 MV光子进行照射。使用盖革计数器测量正电子发射活性，然后建立每种照射材料的放射性衰变曲线。在相同辐射条件下还获得了三种组织模型的正电子发射断层扫描（PET）图像。还对荷瘤兔进行了体内PET成像研究。
我们的结果表明，PET成像可用于在体内验证照射野的位置。使用2 Gy的50 MV光子时，碳和氧光核反应的剂量分布图像是均匀的。
影响各种组织中辐射活性半衰期的因素不同于物理学中的一级动力学反应。
