Ackermann Jakob, Ogura Takahiro, Duerr Robert A, Barbieri Mestriner Alexandre, Gomoll Andreas H
Cartilage Repair Center and Center for Regenerative Medicine, Brigham and Women's Hospital, Harvard Medical School, Harvard University, Boston, MA, USA.
Sports Medicine Center, Funabashi Orthopaedic Hospital, Funabashi, Japan.
Cartilage. 2020 Jul;11(3):309-315. doi: 10.1177/1947603518783484. Epub 2018 Jul 4.
The purpose of this study was to assess potential correlations between the mental component summary of the Short Form-12 (SF-12 MCS), patient characteristics or lesion morphology, and preoperative self-assessed pain and function scores in patients undergoing autologous chondrocyte implantation (ACI).
A total of 290 patients underwent ACI for symptomatic cartilage lesions in the knee. One hundred and seventy-eight patients were included in this study as they completed preoperative SF-12, Knee injury and Osteoarthritis Outcome Score (KOOS), Tegner, Lysholm, and International Knee Documentation Committee (IKDC) scores. Age, sex, smoker status, body mass index, Worker's Compensation, previous surgeries, concomitant surgeries, number of defects, lesion location in the patella, and total defect size were recorded for each patient. Pearson's correlation and multivariate regression models were used to distinguish associations between these factors and preoperative knee scores.
The SF-12 MCS showed the strongest bivariate correlation with all KOOS subgroups ( < 0.001) (except KOOS Symptom; = 0.557), Tegner ( = 0.005), Lysholm ( < 0.001), and IKDC scores ( < 0.001). In the multivariate regression models, the SF-12 MCS showed the strongest association with all KOOS subgroups ( < 0.001) (except KOOS Symptom; = 0.91), Lysholm ( = 0.001), Tegner ( = 0.017), and IKDC ( < 0.001).
In patients with symptomatic cartilage defects of the knee, preoperative patient mental health has a strong association with self-assessed pain and functional knee scores. Further studies are needed to determine if preoperative mental health management can improve preoperative symptoms and postoperative outcomes.
本研究旨在评估接受自体软骨细胞植入（ACI）的患者中，简明健康状况调查简表12项（SF-12）精神健康综合评分、患者特征或损伤形态与术前自我评估的疼痛及功能评分之间的潜在相关性。
共有290例患者因膝关节有症状的软骨损伤接受了ACI治疗。本研究纳入了178例完成术前SF-12、膝关节损伤和骨关节炎疗效评分（KOOS）、特格纳（Tegner）评分、利绍姆（Lysholm）评分以及国际膝关节文献委员会（IKDC）评分的患者。记录了每位患者的年龄、性别、吸烟状况、体重指数、工伤赔偿情况、既往手术史、同期手术情况、缺损数量、髌骨损伤位置以及总缺损大小。采用Pearson相关性分析和多变量回归模型来区分这些因素与术前膝关节评分之间的关联。
SF-12精神健康综合评分与所有KOOS亚组（<0.001）（KOOS症状亚组除外；=0.557）、特格纳评分（=0.005）、利绍姆评分（<0.001）以及IKDC评分（<0.001）的双变量相关性最强。在多变量回归模型中，SF-12精神健康综合评分与所有KOOS亚组（<0.001）（KOOS症状亚组除外；=0.91）、利绍姆评分（=0.001）、特格纳评分（=0.017）以及IKDC评分（<0.001）的关联最强。
在有症状的膝关节软骨缺损患者中，术前患者的心理健康状况与自我评估的膝关节疼痛及功能评分密切相关。需要进一步研究以确定术前心理健康管理是否能改善术前症状及术后结局。
