产后静脉注射免疫球蛋白用于预防多发性硬化症复发并无益处：系统评价与荟萃分析结果
There is no benefit in the use of postnatal intravenous immunoglobulin for the prevention of relapses of multiple sclerosis: findings from a systematic review and meta-analysis.
作者信息
Rosa Gleysson Rodrigues, O'Brien Anthony Terrence, Nogueira Eduardo de Almeida Guimarães, Carvalho Vitor Martinez de, Paz Sonia Castedo, Fragoso Yara Dadalti
机构信息
Harvard Medical School, Spaulding-Labuschagne Neuromodulation Center, Boston, USA.
Universidade Metropolitana de Santos, Departamento de Neurologia, Santos SP, Brasil.
出版信息
Arq Neuropsiquiatr. 2018 Jun;76(6):361-366. doi: 10.1590/0004-282X20180041.
OBJECTIVE
Multiple sclerosis (MS) is a complex autoimmune and neurodegenerative disease of the central nervous system. Since MS affects mostly fertile women, pregnancy issues often arise in daily practice. The present study assessed the use of postpartum intravenous immunoglobulin (IVIG) in MS.
METHODS
The authors individually searched for records using PubMed, Medline, EMBASE, Cochrane, SciELO, LILACS, and Google Scholar, using the terms "multiple sclerosis" OR "MS" AND "pregnancy" OR "gestation" OR "partum" OR "post-partum" OR "puerperium" AND "immunoglobulin".
RESULTS
The initial search returned 321 papers. There were 11 eligible articles selected for the review. In total, 380 patients had received post-natal IVIG to reduce the number of postpartum relapses. The unadjusted number needed to treat was 6.3 for the quantitative and 5.8 for the qualitative analyses.
CONCLUSION
The therapeutic effect of IVIG for prevention of postnatal relapses in MS could not clearly be established in this meta-analysis.
目的
多发性硬化症（MS）是一种中枢神经系统的复杂自身免疫性和神经退行性疾病。由于MS主要影响育龄女性，在日常医疗实践中常常会出现妊娠相关问题。本研究评估了产后静脉注射免疫球蛋白（IVIG）在MS中的应用。
方法
作者分别使用PubMed、Medline、EMBASE、Cochrane、SciELO、LILACS和谷歌学术搜索记录，搜索词为“多发性硬化症”或“MS”以及“妊娠”或“妊娠期”或“产时”或“产后”或“产褥期”以及“免疫球蛋白”。
结果
初步搜索返回321篇论文。有11篇符合条件的文章被选入综述。共有380例患者接受了产后IVIG治疗以减少产后复发次数。定量分析的未调整治疗所需人数为6.3，定性分析为5.8。
结论
在这项荟萃分析中，IVIG预防MS产后复发的治疗效果尚不能明确确定。
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