Huang Z, Huang G S, Wu J, Sang T
Department of Orthodontics, The Affiliated Stomatological Hospital of Nanchang University & The Key Laboratory of Oral Biomedicine, Jiangxi Province, Nanchang 330006, China.
Department of Orthodontics, The Affiliated Stomatological Hospital of Nanchang University & The Key Laboratory of Oral Biomedicine, Jiangxi Province, Nanchang 330006, China(Present address: Department of Stomatology, Ganzhou People' Hospital, Ganzhou Jiangxi 341000, China).
Zhonghua Kou Qiang Yi Xue Za Zhi. 2017 Nov 9;52(11):684-689. doi: 10.3760/cma.j.issn.1002-0098.2017.11.007.
To assess the mandibular condylar growth using cone-beam CT (CBCT) in beagle dogs treated with Herbst appliance and exogenous prostaglandin E2 (PGE2) during late stage of growth. Twenty-four male beagle dogs aged 8 months were divided into four groups according to the random number table (6 in each group): natural growth group, mandibular protraction group (Herbst group), injected prostaglandin E2 group (PGE2 group), mandibular protraction plus injected prostaglandin E2 group (Herbst+PGE2 group). The beagle dogs in Herbst+PGE2 group and PGE2 group were injected 0.1 ml of prostaglandin E2 (dose of 0.05 mg) into bilateral temporomandibular joint articular cavity. The dogs in natural growth group and Herbst group were injected 0.1 ml of saline into bilateral temporomandibular joint articular cavity as control. PGE2 and saline were injected once every 3 days for 60 days, respectively. CBCT was taken before the application of Herbst appliance and after removal of the appliance for all beagle dogs in four groups at the same time. The CBCT images were reconstructed using Invivo5 software and the relevant parameters of temporomandibular joint were measured. No significant difference was found in natural growth group before and after the experiment (0.05). After the treatment, the condylar height and condylar size in Herbst group ([0.19+0.04] and [0.18+0.30] mm), PGE2 group ([0.38+0.14] and [0.51+0.24] mm) and Herbst+PGE2 group ([0.65+0.08] and [0.70+0.24] mm) slightly increased (0.05). The condylar changes in all experimental groups were greater than the natural growth group (0.05), and the ranges of change, in descending order, were Herbst+PGE2 group, PGE2 group and Herbst group (0.05). However, the condylar longitudinal distances, condyle width, condylar transverse diameter, glenoid fossa width and glenoid fossa depth had no statistically significant difference among the four groups (0.05). Injection of exogenous PGE2 into the temporomandibular joint articular cavity, or using Herbst appliance separately, a certain amount of growth was observed on the mandibular condyle in beagle dogs during late stage of growth. The combination of Herbst appliance and exogenous PGE2 injection made the condylar growth more obviously.
使用锥形束CT（CBCT）评估生长后期接受Herbst矫治器和外源性前列腺素E2（PGE2）治疗的比格犬的下颌髁突生长情况。将24只8月龄雄性比格犬根据随机数字表分为四组（每组6只）：自然生长组、下颌前伸组（Herbst组）、注射前列腺素E2组（PGE2组）、下颌前伸加注射前列腺素E2组（Herbst+PGE2组）。Herbst+PGE2组和PGE2组的比格犬双侧颞下颌关节腔注射0.1 ml前列腺素E2（剂量为0.05 mg）。自然生长组和Herbst组的犬双侧颞下颌关节腔注射0.1 ml生理盐水作为对照。PGE2和生理盐水分别每3天注射1次，共60天。对四组所有比格犬在佩戴Herbst矫治器前及去除矫治器后同时进行CBCT扫描。使用Invivo5软件重建CBCT图像并测量颞下颌关节的相关参数。实验前后自然生长组无显著差异（P>0.05）。治疗后，Herbst组（[0.19±0.04]和[0.18±0.30]mm）、PGE2组（[0.38±0.14]和[0.51±0.24]mm）和Herbst+PGE2组（[0.65±0.08]和[0.70±0.24]mm）的髁突高度和髁突大小略有增加（P<0.05）。所有实验组的髁突变化均大于自然生长组（P<0.05），变化幅度由大到小依次为Herbst+PGE2组、PGE2组和Herbst组（P<0.05）。然而，四组之间的髁突纵向距离、髁突宽度、髁突横向直径、关节窝宽度和关节窝深度无统计学显著差异（P>0.05）。向颞下颌关节腔注射外源性PGE2，或单独使用Herbst矫治器，在生长后期的比格犬下颌髁突上观察到一定程度的生长。Herbst矫治器与外源性PGE2注射联合使用使髁突生长更明显。
