Alzghari Saeed K
Gulfstream Genomics, Gulfstream Diagnostics, Dallas, USA.
Cureus. 2018 Apr 30;10(4):e2557. doi: 10.7759/cureus.2557.
Statins are an important class of medications in reducing the risk of cardiovascular events as well as overall mortality. However, a well-known adverse effect of statins is skeletal muscle toxicity, which may lead to abrupt discontinuation of the statin. In turn, patients may miss out on the benefits of statin therapy. An important factor to consider is a patient's solute carrier organic anion transporter 1B1 (SLCO1B1) gene T521C polymorphism status. Herein, an overview of the pharmacogenetics of SLCO1B1 is provided as well as recommendations for use in practice.
他汀类药物是降低心血管事件风险以及总体死亡率的一类重要药物。然而，他汀类药物一个众所周知的不良反应是骨骼肌毒性，这可能导致他汀类药物突然停用。相应地，患者可能无法获得他汀类药物治疗的益处。一个需要考虑的重要因素是患者的溶质载体有机阴离子转运体1B1（SLCO1B1）基因T521C多态性状态。本文提供了SLCO1B1药物遗传学的概述以及在实践中的使用建议。
