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癌症女性的生育力保存:一项关于法国肿瘤学家意识、经验和感受的全国性研究。

Fertility preservation in women with cancer: a national study about French oncologists awareness, experience, and feelings.

机构信息

Sorbonne Paris Cité, Faculté de Médecine, Assistance Publique-Hôpitaux de Paris (AP- HP), Hôpital Universitaire Paris Centre, Centre Hospitalier Universitaire (CHU) Cochin, Service d'Histologie-Embryologie-Biologie de la Reproduction, Université Paris Descartes, Paris, France.

Département "Génomique, Epigénétique et Physiopathologie de la Reproduction," Institut Cochin, INSERM U1016, CNRS UMR8104, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

出版信息

J Assist Reprod Genet. 2018 Oct;35(10):1843-1850. doi: 10.1007/s10815-018-1251-0. Epub 2018 Jul 4.

DOI:10.1007/s10815-018-1251-0
PMID:29974370
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6150902/
Abstract

PURPOSE

This study was designed to evaluate patient management and quality of information given by French oncologists to cancer women concerning fertility issues and possibilities of fertility preservation.

METHODS

An online survey was sent to 1161 physicians in all major cancer centers throughout France between May 2012 and January 2013.

RESULTS

A total of 102 responses were received and analyzed. Only 46% of all physicians surveyed reported discussing infertility risks with patients of reproductive age and 22% referred them to a fertility center before beginning treatments. Only 14% of practitioners considered themselves knowledgeable in FP techniques and ovarian transposition was the most frequently mentioned technique in consultation.

CONCLUSION

This study is at the best of our knowledge the first nationwide survey to assess the state of the art in oncofertility management. It highlights inadequate management of fertility preservation for female patients in France. Physicians reported lacking knowledge and tools that would allow them to provide patients with appropriate information. A better collaboration between cancer and fertility centers needs to be organized in France as already organized in other countries.

摘要

目的

本研究旨在评估法国肿瘤学家向癌症女性提供有关生育问题和生育保存可能性的患者管理和信息质量。

方法

2012 年 5 月至 2013 年 1 月期间,我们向法国所有主要癌症中心的 1161 名医生在线发送了一份调查问卷。

结果

共收到并分析了 102 份回复。只有 46%的被调查医生报告与育龄患者讨论过不孕风险,22%的医生在开始治疗前将患者转介到生育中心。只有 14%的医生认为自己对 FP 技术有足够的了解,在咨询中最常提到的技术是卵巢移位。

结论

据我们所知,这是第一项评估法国生育肿瘤学管理现状的全国性调查。它强调了法国对女性患者生育保存管理的不足。医生报告称缺乏知识和工具,无法为患者提供适当的信息。法国需要像其他国家一样,在癌症和生育中心之间组织更好的合作。

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本文引用的文献

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Fertility preservation and cancer: How many persons are concerned?生育力保存与癌症:涉及多少人?
Eur J Obstet Gynecol Reprod Biol. 2018 Jun;225:232-235. doi: 10.1016/j.ejogrb.2018.05.006. Epub 2018 May 8.
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[Fertility preservation, contraception and menopause hormone therapy in women treated for rare ovarian tumors: Guidelines from the French national network dedicated to rare gynaecological cancer].[罕见卵巢肿瘤女性患者的生育力保存、避孕及绝经激素治疗:法国罕见妇科癌症国家网络指南]
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Expert Rev Anticancer Ther. 2017 Aug;17(8):687-692. doi: 10.1080/14737140.2017.1335199. Epub 2017 Jun 5.
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Reply: Comment on 'Fertility preservation in cancer survivors: a national survey of oncologists' current knowledge, practice and attitudes'--oncologists must not allow personal attitudes to influence discussions on fertility preservation for cancer survivors.回复:对《癌症幸存者的生育力保存:肿瘤学家当前知识、实践与态度的全国性调查》的评论——肿瘤学家绝不应让个人态度影响关于癌症幸存者生育力保存的讨论。
Br J Cancer. 2013 Oct 1;109(7):2021-2. doi: 10.1038/bjc.2013.460. Epub 2013 Aug 13.
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Fertility preservation for patients with cancer: American Society of Clinical Oncology clinical practice guideline update.癌症患者的生育力保存:美国临床肿瘤学会临床实践指南更新。
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[Fertility preservation among patients with cancer: report of a French regional practical experience].[癌症患者的生育力保存:法国某地区实际经验报告]
J Gynecol Obstet Biol Reprod (Paris). 2013 May;42(3):246-51. doi: 10.1016/j.jgyn.2013.01.003. Epub 2013 Feb 28.
7
Racial, socioeconomic, and demographic disparities in access to fertility preservation in young women diagnosed with cancer.在被诊断患有癌症的年轻女性中,在获得生育力保存方面存在种族、社会经济和人口统计学方面的差异。
Cancer. 2012 Sep 15;118(18):4579-88. doi: 10.1002/cncr.26649. Epub 2012 Mar 26.
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Discussing fertility preservation options with patients with cancer.与癌症患者讨论生育力保存方案。
JAMA. 2011 Jul 13;306(2):202-3. doi: 10.1001/jama.2011.973.
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Results from the survey for preservation of adolescent reproduction (SPARE) study: gender disparity in delivery of fertility preservation message to adolescents with cancer.调查结果表明:青少年生殖保护(SPARE)研究——向癌症青少年传递生育力保护信息方面的性别差异。
J Assist Reprod Genet. 2011 Mar;28(3):269-77. doi: 10.1007/s10815-010-9504-6. Epub 2010 Nov 26.
10
A nationwide survey of oncologists regarding treatment-related infertility and fertility preservation in female cancer patients.一项针对全国肿瘤学家的调查,涉及女性癌症患者治疗相关不孕和生育力保存问题。
Fertil Steril. 2010 Oct;94(5):1652-6. doi: 10.1016/j.fertnstert.2009.10.008. Epub 2009 Nov 27.