Aimar María Andrea, Pomiglio Gabriela, Baccaro Fernando, Traverso Mario, Audisio Jorge, De Feo Priscila, Crivelli Adriana, Flores Lazdin Mariela
Nutrihome SA.
Nutr Hosp. 2018 Apr 27;35(3):655-660. doi: 10.20960/nh.1529.
chronic kidney disease (CKD) is a public health problem. Low-protein diets supplemented with ketoacids and essential aminoacids have proved effective at different CKD stages.
to assess the progression of renal failure in adult patients with CKD stages 3b and 4 receiving a protein-controlled diet supplemented with aminoacids and ketoanalogues.
retrospective, descriptive intervention study. The nutritional intervention consisted of a protein/calorie intake of 0.4-0.6 g/kg/day and 30-35 kcal/kg/day plus a tablet of ketoanalogues (Ketosteril®)/5 kg weight. We assessed nutritional condition, glomerular filtration (GF) and creatinine, urea and albumin levels at 0, 3, 6, 9 and 12 months. SPSS version 18 was used for data statistical analysis.
thirty-three patients were studied (67% male; mean age 59.7 years, r: 24-87). Protein/calorie intake was 0.55 ± 0.20 g/kg/day and 34 ± 4.51 kcal/kg/day. Ketosteril® intake was 11.87 tablets/day (r: 9-14). Initial GF was 24.97 ± 6.64 ml/min/1.73 m2, showing a significant increase between three and 12 months (25.51 ± 8.57 and 29.26 ± 10.33 ml/min/1.73 m2; p = 0.006). Urea nitrogen decreased significantly at six months compared with the initial level (p < 0.005). Body mass index did not change significantly (initial, 26. 63 ± 4.08 kg/m2; after a year, 26.78 ± 3.98 kg/m2). Initial and final albumin levels were 3.53 ± 0.64 g/l and 4.00 ± 0.53 g/l, respectively (p = 0.79).
a low-protein diet supplemented with ketoanalogues administered to patients with CKD stages 3b and 4 preserved nutritional condition and mineral balance, improved GF significantly and decreased urea levels.
慢性肾脏病（CKD）是一个公共卫生问题。补充酮酸和必需氨基酸的低蛋白饮食已被证明在不同的CKD阶段是有效的。
评估接受补充氨基酸和酮类似物的蛋白质控制饮食的3b期和4期成年CKD患者肾衰竭的进展情况。
回顾性描述性干预研究。营养干预包括蛋白质/热量摄入量为0.4 - 0.6 g/（kg·天）和30 - 35 kcal/（kg·天），外加每5 kg体重服用一片酮类似物（开同®）。我们在0、3、6、9和12个月时评估营养状况、肾小球滤过率（GF）以及肌酐、尿素和白蛋白水平。使用SPSS 18版进行数据统计分析。
研究了33例患者（67%为男性；平均年龄59.7岁，范围：24 - 87岁）。蛋白质/热量摄入量为0.55±0.20 g/（kg·天）和34±4.51 kcal/（kg·天）。开同®摄入量为11.87片/天（范围：9 - 14片）。初始GF为24.97±6.64 ml/（min·1.73 m²），在3至12个月之间显著增加（分别为25.51±8.57和29.26±10.33 ml/（min·1.73 m²）；p = 0.006）。与初始水平相比，尿素氮在6个月时显著降低（p < 0.005）。体重指数没有显著变化（初始值为26.63±4.08 kg/m²；一年后为26.78±3.98 kg/m²）。初始和最终白蛋白水平分别为3.53±0.64 g/l和4.00±0.53 g/l（p = 0.79）。
对3b期和4期CKD患者给予补充酮类似物的低蛋白饮食可维持营养状况和矿物质平衡，显著改善GF并降低尿素水平。
