经心内膜 CD34 细胞移植治疗非致密化心肌病：首例人体病例研究。
Transendocardial CD34 Cell Transplantation in Noncompaction Cardiomyopathy: First-in-Man Case Study.
机构信息
1 Advanced Heart Failure and Transplantation Center, Department of Cardiology, UMC Ljubljana, Ljubljana, Slovenia.
2 Department of Hematology, UMC Ljubljana, Ljubljana, Slovenia.
出版信息
Cell Transplant. 2018 Jul;27(7):1027-1030. doi: 10.1177/0963689718779349. Epub 2018 Jul 5.
Abstract
Noncompaction cardiomyopathy is a rare congenital heart disorder characterized by an arrest of the myocardial compaction process. This results in the altered formation of coronary microvessels with a resulting decrease in myocardial perfusion. Transendocardial CD34 cell transplantation has been shown to increase myocardial perfusion and function in patients with non-ischemic heart failure. In our first-in-man case study, we investigated the feasibility, safety and clinical effect of transendocardial CD34 cell therapy in a patient with noncompaction cardiomyopathy.
摘要
非致密性心肌病是一种罕见的先天性心脏疾病，其特征是心肌致密化过程停止。这导致冠状动脉微血管形成异常，心肌灌注减少。经心内膜 CD34 细胞移植已被证明可增加非缺血性心力衰竭患者的心肌灌注和功能。在我们的首例人体病例研究中，我们研究了经心内膜 CD34 细胞治疗在非致密性心肌病患者中的可行性、安全性和临床效果。
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