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经心内膜 CD34 细胞移植治疗非致密化心肌病：首例人体病例研究。

Transendocardial CD34 Cell Transplantation in Noncompaction Cardiomyopathy: First-in-Man Case Study.

机构信息

1 Advanced Heart Failure and Transplantation Center, Department of Cardiology, UMC Ljubljana, Ljubljana, Slovenia.

2 Department of Hematology, UMC Ljubljana, Ljubljana, Slovenia.

出版信息

Cell Transplant. 2018 Jul;27(7):1027-1030. doi: 10.1177/0963689718779349. Epub 2018 Jul 5.

DOI:10.1177/0963689718779349
PMID:29974792
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6158552/
Abstract

Noncompaction cardiomyopathy is a rare congenital heart disorder characterized by an arrest of the myocardial compaction process. This results in the altered formation of coronary microvessels with a resulting decrease in myocardial perfusion. Transendocardial CD34 cell transplantation has been shown to increase myocardial perfusion and function in patients with non-ischemic heart failure. In our first-in-man case study, we investigated the feasibility, safety and clinical effect of transendocardial CD34 cell therapy in a patient with noncompaction cardiomyopathy.

摘要

非致密性心肌病是一种罕见的先天性心脏疾病，其特征是心肌致密化过程停止。这导致冠状动脉微血管形成异常，心肌灌注减少。经心内膜 CD34 细胞移植已被证明可增加非缺血性心力衰竭患者的心肌灌注和功能。在我们的首例人体病例研究中，我们研究了经心内膜 CD34 细胞治疗在非致密性心肌病患者中的可行性、安全性和临床效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcf5/6158552/8d68e72273fb/10.1177_0963689718779349-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcf5/6158552/4a6fb00a99b5/10.1177_0963689718779349-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcf5/6158552/8d68e72273fb/10.1177_0963689718779349-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcf5/6158552/4a6fb00a99b5/10.1177_0963689718779349-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcf5/6158552/8d68e72273fb/10.1177_0963689718779349-fig2.jpg

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本文引用的文献

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LVAD as a Bridge to Heart Transplantation in a Patient with Left Ventricular Noncompaction Cardiomyopathy and Advanced Heart Failure.左心室致密化不全心肌病合并晚期心力衰竭患者应用左心室辅助装置作为心脏移植的过渡治疗
Heart Surg Forum. 2016 Jun 24;19(3):E128-30. doi: 10.1532/hsf.1563.
2
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC.2016欧洲心脏病学会急性和慢性心力衰竭诊断与治疗指南：欧洲心脏病学会（ESC）急性和慢性心力衰竭诊断与治疗工作组编写，欧洲心脏病学会心力衰竭协会（HFA）提供特别贡献。
Eur Heart J. 2016 Jul 14;37(27):2129-2200. doi: 10.1093/eurheartj/ehw128. Epub 2016 May 20.
3
Left ventricular non-compaction cardiomyopathy.左心室心肌致密化不全心肌病。
Lancet. 2015 Aug 22;386(9995):813-25. doi: 10.1016/S0140-6736(14)61282-4. Epub 2015 Apr 9.
4
Intracoronary transplantation of CD34(+) cells is associated with improved myocardial perfusion in patients with nonischemic dilated cardiomyopathy.在非缺血性扩张型心肌病患者中，冠状动脉内移植CD34(+)细胞与心肌灌注改善相关。
J Card Fail. 2015 Feb;21(2):145-52. doi: 10.1016/j.cardfail.2014.11.005. Epub 2014 Nov 18.
5
Abnormalities of myocardial perfusion and glucose metabolism in patients with isolated left ventricular non-compaction.孤立性左心室心肌致密化不全患者的心肌灌注和葡萄糖代谢异常。
J Nucl Cardiol. 2014 Jun;21(3):633-42. doi: 10.1007/s12350-014-9890-8. Epub 2014 Apr 11.
6
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7
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8
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9
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J Clin Ultrasound. 2007 Oct;35(8):465-8. doi: 10.1002/jcu.20349.
10
Isolated ventricular noncompaction is associated with coronary microcirculatory dysfunction.孤立性心室肌致密化不全与冠状动脉微循环功能障碍有关。
J Am Coll Cardiol. 2002 Feb 6;39(3):450-4. doi: 10.1016/s0735-1097(01)01765-x.