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ST段抬高型心肌梗死患者碱性磷酸酶与冠状动脉血流受损之间的关系

Relationship between alkaline phosphatase and impaired coronary flow in patients with ST-segment elevated myocardial infarction.

作者信息

Edem Efe

机构信息

Cardiology Department, İzmir Tınaztepe Hospital, Turkey.

出版信息

J Int Med Res. 2018 Sep;46(9):3918-3927. doi: 10.1177/0300060518785544. Epub 2018 Jul 5.

DOI:10.1177/0300060518785544
PMID:29974807
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6136034/
Abstract

Objective Recent studies have shown that alkaline phosphatase (ALP) might play a negative role in clinical outcomes of patients with peripheral and coronary artery disease. This study aimed to investigate the relationship between serum ALP levels and coronary thrombolysis in myocardial infarction (TIMI) frame counts in patients with ST-segment elevated myocardial infarction undergoing primary percutaneous coronary intervention (PCI). Methods A total of 198 patients were enrolled in the current study. Serum ALP levels were measured in lithium-heparin plasma samples via a standardized, colorimetric enzyme assay. Coronary TIMI flow was evaluated by counting the number of cine frames that were required for contrast to reach a standardized distal coronary landmark in the culprit vessel. Results The Spearman correlation coefficient test showed strong positive relationships between coronary TIMI frame counts after primary PCI and serum ALP levels on admittance for the left anterior descending, circumflex, and right coronary arteries (r = 0.774, r = 0.831, and r = 0.730, respectively). Conclusion Elevated serum ALP levels appear to be a predictor of impaired coronary TIMI frame count in patients suffering from ST-segment elevated myocardial infarction.

摘要

目的 近期研究表明，碱性磷酸酶（ALP）可能在周围血管疾病和冠状动脉疾病患者的临床预后中发挥负面作用。本研究旨在探讨接受直接经皮冠状动脉介入治疗（PCI）的ST段抬高型心肌梗死患者血清ALP水平与心肌梗死溶栓治疗（TIMI）帧数之间的关系。方法 本研究共纳入198例患者。通过标准化比色酶法测定锂肝素血浆样本中的血清ALP水平。通过计算造影剂到达罪犯血管中标准化冠状动脉远端标志物所需的电影帧数来评估冠状动脉TIMI血流。结果 斯皮尔曼相关系数检验显示，直接PCI后左前降支、回旋支和右冠状动脉的冠状动脉TIMI帧数与入院时血清ALP水平呈强正相关（分别为r = 0.774、r = 0.831和r = 0.730）。结论 血清ALP水平升高似乎是ST段抬高型心肌梗死患者冠状动脉TIMI帧数受损的一个预测指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d32/6136034/c7f5c9d8f772/10.1177_0300060518785544-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d32/6136034/6e111f59d626/10.1177_0300060518785544-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d32/6136034/b7ad73977e48/10.1177_0300060518785544-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d32/6136034/2bb0c87e37ba/10.1177_0300060518785544-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d32/6136034/20b28e81cda9/10.1177_0300060518785544-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d32/6136034/83fe57b762a3/10.1177_0300060518785544-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d32/6136034/c7f5c9d8f772/10.1177_0300060518785544-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d32/6136034/6e111f59d626/10.1177_0300060518785544-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d32/6136034/b7ad73977e48/10.1177_0300060518785544-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d32/6136034/2bb0c87e37ba/10.1177_0300060518785544-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d32/6136034/20b28e81cda9/10.1177_0300060518785544-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d32/6136034/83fe57b762a3/10.1177_0300060518785544-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d32/6136034/c7f5c9d8f772/10.1177_0300060518785544-fig6.jpg

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