Department of Epidemiology,University of Florida,Gainesville,USA.
U.S. Department of Defense,Army Public Health Center,Army Medical Command,Edgewood,USA.
Epidemiol Infect. 2018 Oct;146(14):1854-1860. doi: 10.1017/S0950268818001838. Epub 2018 Jul 5.
The adenovirus vaccine and benzathine penicillin G (BPG) have been used by the US military to prevent acute respiratory diseases (ARD) in trainees, though these interventions have had documented manufacturing problems. We fit Poisson regression and random forest models (RF) to 26 years of weekly ARD incidence data to explore the impact of the adenovirus vaccine and BPG prophylaxis on respiratory disease burden. Adenovirus vaccine availability was among the most important predictors of ARD in the RF, while BPG was the ninth most important. BPG was a significant protective factor against ARD (incidence rate ratio (IRR) = 0.68; 95% confidence interval (CI) 0.67-0.70), but less so than either the old or new adenovirus vaccine (IRR = 0.39, 95% CI 0.38-0.39 and IRR = 0.11, 95% CI 0.11-0.11), respectively. These results suggest that BPG is moderately predictive of, and significantly protective against ARD, though to a lesser extent than either the old or new adenovirus vaccine.
腺病毒疫苗和苄星青霉素 G（BPG）已被美国军方用于预防新兵的急性呼吸道疾病（ARD），尽管这些干预措施已经有文件记录的制造问题。我们使用泊松回归和随机森林模型（RF）对 26 年的每周 ARD 发病率数据进行拟合，以探讨腺病毒疫苗和 BPG 预防措施对呼吸道疾病负担的影响。RF 中的腺病毒疫苗可及性是 ARD 的最重要预测因素之一，而 BPG 是第九个最重要的因素。BPG 是 ARD 的显著保护因素（发病率比（IRR）= 0.68；95%置信区间（CI）0.67-0.70），但不如旧的或新的腺病毒疫苗（IRR = 0.39，95% CI 0.38-0.39 和 IRR = 0.11，95% CI 0.11-0.11）。这些结果表明，BPG 对 ARD 具有中等预测性和显著的保护作用，但不如旧的或新的腺病毒疫苗。
Zotero 插件