Urology Unit, Department of Medico-Surgical Sciences and Biotechnologies, ICOT, Faculty of Pharmacy and Medicine, "Sapienza" University of Rome, Latina (LT) 04100, Italy.
Uroresearch, Nonprofit Association for Research in Urology, Latina 04100, Italy.
Asian J Androl. 2018 Nov-Dec;20(6):572-575. doi: 10.4103/aja.aja_30_18.
The aim of the study was to evaluate the long-term outcomes of pelvic floor muscle (PFM) rehabilitation in males with lifelong premature ejaculation (PE), using intravaginal ejaculatory latency time (IELT) and the self-report Premature Ejaculation Diagnostic Tool (PEDT) as primary outcomes. A total of 154 participants were retrospectively reviewed in this study, with 122 completing the training protocol. At baseline, all participants had an IELT ≤60 s and PEDT score >11. Participants completed a 12-week program of PFM rehabilitation, including physio-kinesiotherapy treatment, electrostimulation, and biofeedback, with three sessions per week, with 20 min for each component completed at each session. The effectiveness of intervention was evaluated by comparing the change in the geometric mean of IELT and PEDT values, from baseline, at 3, 6, and 12 months during the intervention, and at 24 and 36 months postintervention, using a paired sample 2-tailed t-test, including the associated 95% confidence intervals. Of the 122 participants who completed PFM rehabilitation, 111 gained control of their ejaculation reflex, with a mean IELT of 161.6 s and PEDT score of 2.3 at the 12-week endpoint of the intervention, representing an increase from baseline of 40.4 s and 17.0 scores, respectively, for IELT and PEDT (P < 0.0001). Of the 95 participants who completed the 36-month follow-up, 64% and 56% maintained satisfactory ejaculation control at 24 and 36 months postintervention, respectively.
本研究旨在评估针对终身性早泄（PE）男性进行盆底肌（PFM）康复治疗的长期疗效，采用阴道内射精潜伏期时间（IELT）和自我报告的早泄诊断工具（PEDT）作为主要结局指标。本研究共回顾性分析了 154 名参与者，其中 122 名完成了训练方案。基线时，所有参与者的 IELT≤60s，PEDT 评分>11。参与者完成了 12 周的 PFM 康复计划，包括物理运动疗法治疗、电刺激和生物反馈，每周 3 次，每次 20 分钟，每个部分在每次治疗中完成。通过比较干预期间从基线到 3、6 和 12 个月以及干预后 24 和 36 个月的 IELT 和 PEDT 值的几何均数变化，使用配对样本 2 尾 t 检验评估干预的有效性，包括相关的 95%置信区间。在完成 PFM 康复的 122 名参与者中，有 111 名参与者控制了射精反射，干预 12 周结束时的平均 IELT 为 161.6s，PEDT 评分为 2.3，分别比基线时增加了 40.4s 和 17.0 分，IELT 和 PEDT 的变化均具有统计学意义（P<0.0001）。在完成 36 个月随访的 95 名参与者中，分别有 64%和 56%的参与者在干预后 24 和 36 个月时维持了满意的射精控制。
