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高产 F 放射性标记合成新型催产素受体示踪剂，用于体内鼻内催产素摄取的探针。

High-yielding F radiosynthesis of a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptake in vivo.

机构信息

Department of Chemistry, Imperial College London, Exhibition Road, London, SW7 2AZ, UK.

出版信息

Chem Commun (Camb). 2018 Jul 17;54(58):8120-8123. doi: 10.1039/c8cc01400k.

DOI:10.1039/c8cc01400k
PMID:29974895
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6049614/
Abstract

A novel Al18F labelled peptide tracer for PET imaging of oxytocin receptor has been accessed through a high radiochemical yield approach. This tracer showed comparable affinity and higher selectivity and stability compared to oxytocin, and was used to demonstrate direct nose-to-brain uptake following intranasal administration, a common yet controversial delivery route for oxytocin-based therapeutics.

摘要

一种新型的 Al18F 标记的催产素受体 PET 成像肽示踪剂，通过高放射化学产率方法获得。与催产素相比，该示踪剂显示出相当的亲和力和更高的选择性和稳定性，并用于证明经鼻内给药后的直接鼻脑摄取，这是一种常见但有争议的基于催产素的治疗药物的给药途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26aa/6049614/df1f7902e8ac/c8cc01400k-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26aa/6049614/9778297c6165/c8cc01400k-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26aa/6049614/629e4671b151/c8cc01400k-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26aa/6049614/732bc5690def/c8cc01400k-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26aa/6049614/df1f7902e8ac/c8cc01400k-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26aa/6049614/9778297c6165/c8cc01400k-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26aa/6049614/629e4671b151/c8cc01400k-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26aa/6049614/732bc5690def/c8cc01400k-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26aa/6049614/df1f7902e8ac/c8cc01400k-f4.jpg

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