Sheon R P, Kirsner A B, Tangsintanapas P, Samad F, Garg M L, Finkel R I
J Am Geriatr Soc. 1977 Jan;25(1):20-7. doi: 10.1111/j.1532-5415.1977.tb00918.x.
Patients with inflammatory arthritis and malignancy comprise two distinct populations. One group represents the chance occurrence of malignancy and rheumatic disease. These patients have symmetric polyarthritis, chiefly classic rheumatoid arthritis, and react positively to the rheumatoid factor test. There is no temporal relationship between tumor onset and rheumatic disease onset. In the second group, there may be a causal relationship between the malignancy and the rheumatic disease. These patients have asymmetric rather than symmetric arthritis and test results are negative for rheumatoid factor. There is a close temporal relationship between the onset of the tumor and the onset of the rheumatic disease. The mortality rate is significantly higher than in patients with symmetric polyarthritis. In 80 percent of women with asymmetric arthritis and malignancy, the tumor is mammary carcinoma. This indicates the advisability of a careful breast examination in this group of women.
患有炎性关节炎和恶性肿瘤的患者可分为两个不同群体。一组是恶性肿瘤和风湿性疾病偶然同时出现。这些患者患有对称性多关节炎，主要是典型的类风湿关节炎，类风湿因子检测呈阳性反应。肿瘤发病与风湿性疾病发病之间没有时间关联。在第二组中，恶性肿瘤与风湿性疾病之间可能存在因果关系。这些患者患的是不对称性而非对称性关节炎，类风湿因子检测结果为阴性。肿瘤发病与风湿性疾病发病之间存在密切的时间关联。其死亡率显著高于对称性多关节炎患者。在患有不对称性关节炎和恶性肿瘤的女性中，80% 的肿瘤是乳腺癌。这表明对这组女性进行仔细的乳房检查是明智的。
