Hayakawa M, Morise K, Iizuka A, Inagaki T, Nakura E, Nishikawa H, Ohno R, Hayashi N, Tunekawa H, Kato H
Gan No Rinsho. 1985 Aug;31(10):1263-70.
Sequential chemotherapy with low-dose methotrexate (30 mg/body) and 5-FU (750 mg/m2) was undertaken in 16 patients with advanced gastric cancer. Following the chemotherapy, leucovorin (30 mg/body) was injected intravenously. These treatment were repeated weekly for two to eight weeks. Out of 16 patients, two partial remissions and two minor responses were obtained. The overall response rate was 12.5%. There were no cases of renal or hematologic toxicity. The only adverse effect was nausea. We concluded therefore, that sequential chemotherapy with low-dose methotrexate and 5-FU is a useful method for advanced gastric cancer.
对16例晚期胃癌患者采用低剂量甲氨蝶呤（30mg/体）和5-氟尿嘧啶（750mg/m²）进行序贯化疗。化疗后，静脉注射亚叶酸钙（30mg/体）。这些治疗每周重复进行，持续两至八周。16例患者中，获得了2例部分缓解和2例轻度缓解。总缓解率为12.5%。没有出现肾毒性或血液学毒性病例。唯一的不良反应是恶心。因此，我们得出结论，低剂量甲氨蝶呤和5-氟尿嘧啶序贯化疗是治疗晚期胃癌的一种有效方法。
