Kishioka S, Tamura S, Iguchi Y, Ozaki M, Yamamoto H
Jpn J Pharmacol. 1985 Jul;38(3):334-6. doi: 10.1254/jjp.38.334.
The effects of morphine, adrenocorticotropic hormone (ACTH) and formalin on plasma corticosterone levels were investigated in the nucleus reticularis gigantocellularis (NRGC)-lesioned rats. ACTH (1.0 U/kg) or formalin (6.4%, 0.2 ml/rat) elevated plasma corticosterone in both sham-lesioned and NRGC-lesioned rats at the same degree, while morphine (10 mg/kg) also elevated plasma corticosterone in sham-lesioned rats, the elevation of which was significantly reduced by NRGC-lesioning. These findings suggest that the NRGC is involved in the corticosterone-increasing effect of morphine, but not involved in the effect of ACTH or formalin.
研究了吗啡、促肾上腺皮质激素（ACTH）和福尔马林对巨细胞网状核（NRGC）损伤大鼠血浆皮质酮水平的影响。ACTH（1.0 U/kg）或福尔马林（6.4%，0.2 ml/只大鼠）在假损伤和NRGC损伤大鼠中均以相同程度升高血浆皮质酮，而吗啡（10 mg/kg）在假损伤大鼠中也升高血浆皮质酮，NRGC损伤显著降低了其升高幅度。这些发现表明，NRGC参与了吗啡升高皮质酮的作用，但不参与ACTH或福尔马林的作用。
