Lehrstuhl für Organische Chemie I , Ruhr-Universität Bochum , ZEMOS, Universitätsstr. 150 , 44801 Bochum , Germany.
Org Lett. 2018 Jul 20;20(14):4337-4340. doi: 10.1021/acs.orglett.8b01762. Epub 2018 Jul 5.
A facile insertion of ruthenium into aromatic C-H and allylic C-N bonds are the key steps in a [Ru( p-cymene)Cl]-catalyzed ortho-C-H allylation of benzoic acids. This protocol allows drawing on the large pool of allylic amines for state-of-the-art ortho-functionalizations of arenes, turning neutral amines into leaving groups. Concise syntheses of biologically active compounds provide further evidence of the synthetic potential of this methodology.
在[Ru( p-cymene)Cl]催化的苯甲酸邻位 C-H 烯丙基化反应中，Ru 原子容易插入芳基 C-H 和烯丙基 C-N 键中，这是关键步骤。该方案利用了大量的烯丙基胺作为芳基邻位官能团化的最新方法，将中性胺转化为离去基团。生物活性化合物的简洁合成进一步证明了该方法的合成潜力。
