一种抑制性苯二氮䓬类药物的惊厥成分。
Convulsant component of a depressant benzodiazepine.
作者信息
Garrett R L, Bourn W M
出版信息
Life Sci. 1985 Nov 18;37(20):1933-9. doi: 10.1016/0024-3205(85)90011-6.
The convulsant influence of high doses of diazepam, in the presence of the benzodiazepine receptor antagonist Ro 15-1788, was studied in rats. Animals were implanted with permanent cortical screw electrodes for EEG recording. EEG spiking and accompanying clonic activity was observed in rats receiving greater than or equal to 200 mg/kg diazepam, followed 10 minutes later by Ro 15-1788 (20 mg/kg). Pentylenetetrazole and picrotoxin seizure thresholds, measured during constant rate iv infusion, were significantly lowered by pretreatment with diazepam (250 mg/kg) and Ro 15-1788 (20 mg/kg) administered 30 and 20 minutes, respectively, before seizure threshold measurement. It is proposed that this convulsive activity of diazepam is mediated through the picrotoxinin receptor.
在大鼠中研究了在苯二氮䓬受体拮抗剂Ro 15 - 1788存在的情况下高剂量地西泮的惊厥作用。给动物植入永久性皮质螺旋电极用于脑电图记录。在接受大于或等于200mg/kg地西泮的大鼠中观察到脑电图尖峰和伴随的阵挛活动，10分钟后给予Ro 15 - 1788（20mg/kg）。在恒速静脉输注期间测量的戊四氮和印防己毒素惊厥阈值，分别在惊厥阈值测量前30分钟和20分钟用250mg/kg地西泮和20mg/kg Ro 15 - 1788预处理后显著降低。有人提出地西泮的这种惊厥活性是通过印防己毒素受体介导的。
Zotero 插件