Lee Yun Im, Jeon Hong Kil, Im Jae Wook, Oh Sang Yu, Kim Kyung Bin, Kim Byunggyu
Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
Department of Pathology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
Clin Endosc. 2019 Jan;52(1):76-79. doi: 10.5946/ce.2018.062. Epub 2018 Jul 6.
Primary gastric small cell carcinoma (GSCC) is one of the gastroenteropancreatic neuroendocrine tumors. It is a rare cancer with a very aggressive behavior and a poor prognosis because of the high rate of metastases. It is usually found in far advanced stage. We experienced a case of GSCC which had developed into a large subepithelial tumor (SET) from invisible state in a short period. A 65-year-old man consulted our hospital because of early gastric cancer. He underwent endoscopic submucosal dissection for the early gastric cancer at high body posterior wall. After 6 months, the follow-up endoscopy showed a large newly developed SET-like lesion with central ulceration at the gastric cardia. Endoscopic biopsy revealed GSCC. Total gastrectomy was performed. One out of the 26 perigastric lymph nodes had a metastasis. He received 6 cycles of adjuvant chemotherapy with etoposide and cisplatin. He is still in good health 12 months after operation.
原发性胃小细胞癌（GSCC）是胃肠胰神经内分泌肿瘤之一。它是一种罕见的癌症，行为极具侵袭性，由于转移率高，预后较差。它通常在晚期才被发现。我们遇到一例GSCC，在短时间内从不可见状态发展为巨大的黏膜下肿瘤（SET）。一名65岁男性因早期胃癌前来我院就诊。他因高位体后壁早期胃癌接受了内镜黏膜下剥离术。6个月后，随访内镜检查显示胃贲门处有一个新出现的巨大SET样病变，中央有溃疡。内镜活检显示为GSCC。遂行全胃切除术。26个胃周淋巴结中有1个发生转移。他接受了6个周期的依托泊苷和顺铂辅助化疗。术后12个月他仍健康状况良好。
