Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan.
Graduate Institute of Food Safety, National Chung Hsing University, Taichung, Taiwan.
J Food Drug Anal. 2018 Jul;26(3):940-964. doi: 10.1016/j.jfda.2018.05.003. Epub 2018 Jun 1.
From several decades ago to now, cancer continues to be the leading cause of death worldwide, and metastasis is the major cause of cancer-related deaths. For health benefits, there is a great desire to use non-chemical therapy such as nutraceutical supplementation to prevent pathology development. Over 10,000 different natural bioactives or phytochemicals have been known that possessing potential preventive or supplementary effects for various diseases including cancer. Previously, the in vitro and in vivo anti-invasive and anti-metastatic activities of phenolic acids, monophenol, polyphenol and their derivatives and flavonoids and their derivatives have been reviewed. However, a vast number of natural dietary compounds other than phenolics have been demonstrated to potentially possess the ability to inhibit the invasion and metastasis of various cancers. In this review, we summarize the studies in recent decade on in vitro and in vivo effects and molecular mechanisms of natural bioactives, excluding the phenolics in food, in cancer invasion and metastasis. By combining this review of non-phenolics with the previous phenolics reviews, the puzzle for the contribution of natural dietary bioactives on cancer invasive or/and metastatic progress will be almost complete and more clear.
从几十年前到现在，癌症一直是全球主要的死亡原因，而转移是癌症相关死亡的主要原因。为了健康益处，人们非常希望使用非化学疗法，如营养补充剂来预防病理发展。目前已知有超过 10000 种不同的天然生物活性物质或植物化学物质，它们具有预防或辅助治疗包括癌症在内的各种疾病的潜力。此前，已经综述了酚酸、单酚、多酚及其衍生物以及黄酮类化合物及其衍生物的体外和体内抗侵袭和抗转移活性。然而，大量除了酚类之外的天然膳食化合物已被证明具有抑制各种癌症侵袭和转移的潜力。在这篇综述中，我们总结了近十年来关于天然生物活性物质在癌症侵袭和转移中的体外和体内作用及其分子机制的研究，这些天然生物活性物质不包括食物中的酚类。通过将这篇非酚类综述与之前的酚类综述相结合，关于天然膳食生物活性物质对癌症侵袭和/或转移进展的贡献的谜题将几乎完全解开，并且更加清晰。
