Huidobro-Toro J P
Neurosci Lett. 1985 Sep 6;59(3):247-52. doi: 10.1016/0304-3940(85)90139-9.
The inhibitory action of neuropeptide Y (NPY) on the muscular activity of the prostatic end of the rat vas deferens elicited by transmural electrical stimulation was examined in control and in reserpinized rats. Pretreatment with 1 mg/kg reserpine for 48 h induced a 6-fold increase in NPY potency. Likewise, the potency of clonidine to inhibit the electrically induced muscular activity or noradrenaline to contract the ductus musculature was also potentiated. It is hypothesized that reserpine via a denervation super-sensitivity-like process increases the density of the NPY receptors. The functional significance of NPY in the motor activity of the vas deferens is discussed.
在对照大鼠和利血平化大鼠中，研究了神经肽Y（NPY）对经壁电刺激诱发的大鼠输精管前列腺端肌肉活动的抑制作用。用1mg/kg利血平预处理48小时可使NPY的效力增加6倍。同样，可乐定抑制电诱发肌肉活动的效力或去甲肾上腺素使输精管肌肉收缩的效力也增强。据推测，利血平通过类似去神经超敏反应的过程增加了NPY受体的密度。文中讨论了NPY在输精管运动活动中的功能意义。
