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Development of angiotensin II (1-7) analog as an oral therapeutic for the treatment of chemotherapy-induced myelosuppression.血管紧张素II（1-7）类似物作为治疗化疗引起的骨髓抑制的口服疗法的研发。
Haematologica. 2018 Dec;103(12):e567-e570. doi: 10.3324/haematol.2018.193771. Epub 2018 Jul 5.
2
Angiotensin-(1-7) synergizes with colony-stimulating factors in hematopoietic recovery.血管紧张素-(1-7)与集落刺激因子协同作用促进造血恢复。
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3
Synergistic effects of co-administration of angiotensin 1-7 and Neupogen on hematopoietic recovery in mice.
Cancer Chemother Pharmacol. 2004 Jan;53(1):15-24. doi: 10.1007/s00280-003-0710-0. Epub 2003 Oct 16.
4
Association of an oral formulation of angiotensin-(1-7) with atenolol improves lipid metabolism in hypertensive rats.血管紧张素 -（1 - 7）口服制剂与阿替洛尔联用可改善高血压大鼠的脂质代谢。
Peptides. 2013 May;43:155-9. doi: 10.1016/j.peptides.2013.03.009. Epub 2013 Mar 18.
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Proteomic white adipose tissue analysis of obese mice fed with a high-fat diet and treated with oral angiotensin-(1-7).对喂食高脂饮食并接受口服血管紧张素 -（1 - 7）治疗的肥胖小鼠进行白色脂肪组织蛋白质组学分析。
Peptides. 2014 Oct;60:56-62. doi: 10.1016/j.peptides.2014.07.023. Epub 2014 Aug 4.
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Accelerated hematopoietic recovery with angiotensin-(1-7) after total body radiation.全身放射后血管紧张素-(1-7)加速造血恢复。
Int J Radiat Biol. 2012 Jun;88(6):466-76. doi: 10.3109/09553002.2012.676228. Epub 2012 Apr 30.
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Oral administration of angiotensin-(1-7) ameliorates type 2 diabetes in rats.口服血管紧张素-(1-7)可改善大鼠 2 型糖尿病。
J Mol Med (Berl). 2014 Mar;92(3):255-65. doi: 10.1007/s00109-013-1087-0. Epub 2013 Oct 27.
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Oral formulation of angiotensin-(1-7) improves lipid metabolism and prevents high-fat diet-induced hepatic steatosis and inflammation in mice.血管紧张素-(1-7)口服制剂可改善脂代谢，预防高脂饮食诱导的小鼠肝脂肪变性和炎症。
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A role for the renin-angiotensin system in hematopoiesis.肾素-血管紧张素系统在造血过程中的作用。
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AVE0991, a nonpeptide angiotensin-(1-7) mimic, inhibits angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E knockout mice.AVE0991，一种非肽类血管紧张素-(1-7)类似物，可抑制载脂蛋白 E 敲除小鼠血管紧张素 II 诱导的腹主动脉瘤形成。
J Mol Med (Berl). 2020 Apr;98(4):541-551. doi: 10.1007/s00109-020-01880-4. Epub 2020 Feb 14.

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1
High-altitude hypoxia exacerbates chemotherapy-induced myelosuppression by lowering serum G-CSF/GM-CSF and regulating apoptosis and proliferation.高原缺氧通过降低血清G-CSF/GM-CSF水平以及调节细胞凋亡和增殖，加剧化疗诱导的骨髓抑制。
Discov Oncol. 2025 May 28;16(1):938. doi: 10.1007/s12672-025-02611-2.
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Angiotensin-(1-7) decreases inflammation and lung damage caused by betacoronavirus infection in mice.血管紧张素-(1-7)可降低小鼠β冠状病毒感染引起的炎症和肺损伤。
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The potential role of renin angiotensin system in acute leukemia: a narrative review.肾素血管紧张素系统在急性白血病中的潜在作用：一篇叙述性综述。
Mol Biol Rep. 2024 Jun 21;51(1):775. doi: 10.1007/s11033-024-09659-3.
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The Counteracting Effects of Ang II and Ang-(1-7) on the Function andGrowth of Insulin-secreting NIT-1 Cells.血管紧张素 II（Ang II）和血管紧张素-(1-7)（Ang-(1-7)）对胰岛素分泌细胞 NIT-1 功能和生长的拮抗作用。
Curr Diabetes Rev. 2024;20(10):e010124225112. doi: 10.2174/0115733998276291231204115314.
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Glycopeptide drugs: A pharmacological dimension between "Small Molecules" and "Biologics".糖肽类药物：“小分子”与“生物制剂”之间的药理学维度。
Peptides. 2020 Sep;131:170369. doi: 10.1016/j.peptides.2020.170369. Epub 2020 Jul 13.

本文引用的文献

1
Angiotensin II Regulation of Proliferation, Differentiation, and Engraftment of Hematopoietic Stem Cells.血管紧张素II对造血干细胞增殖、分化和植入的调控
Hypertension. 2016 Mar;67(3):574-84. doi: 10.1161/HYPERTENSIONAHA.115.06474. Epub 2016 Jan 18.
2
Managing thrombocytopenia associated with cancer chemotherapy.处理与癌症化疗相关的血小板减少症
Oncology (Williston Park). 2015 Apr;29(4):282-94.
3
Model-based approach to early predict prolonged high grade neutropenia in carboplatin-treated patients and guide G-CSF prophylactic treatment.基于模型的方法用于早期预测卡铂治疗患者的长期重度中性粒细胞减少症并指导粒细胞集落刺激因子预防性治疗。
Pharm Res. 2015 Feb;32(2):654-64. doi: 10.1007/s11095-014-1493-1. Epub 2014 Sep 4.
4
The bone marrow niche for haematopoietic stem cells.造血干细胞的骨髓龛。
Nature. 2014 Jan 16;505(7483):327-34. doi: 10.1038/nature12984.
5
Contribution of the Local RAS to Hematopoietic Function: A Novel Therapeutic Target.局部肾素-血管紧张素系统对造血功能的作用：一个新的治疗靶点。
Front Endocrinol (Lausanne). 2013 Oct 23;4:157. doi: 10.3389/fendo.2013.00157.
6
Angiotensin-(1-7) synergizes with colony-stimulating factors in hematopoietic recovery.血管紧张素-(1-7)与集落刺激因子协同作用促进造血恢复。
Cancer Chemother Pharmacol. 2013 Dec;72(6):1235-45. doi: 10.1007/s00280-013-2312-9. Epub 2013 Oct 5.
7
Pharmacodynamic stimulation of thrombogenesis by angiotensin (1-7) in recurrent ovarian cancer patients receiving gemcitabine and platinum-based chemotherapy.血管紧张素(1-7)对接受吉西他滨和铂类化疗的复发性卵巢癌患者血栓形成的药效学刺激。
Cancer Chemother Pharmacol. 2013 Apr;71(4):965-72. doi: 10.1007/s00280-013-2089-x. Epub 2013 Jan 31.
8
Erythropoietin use and abuse.促红细胞生成素的使用与滥用。
Indian J Endocrinol Metab. 2012 Mar;16(2):220-7. doi: 10.4103/2230-8210.93739.
9
Cyclodextrins in delivery systems: Applications.递送系统中的环糊精：应用
J Pharm Bioallied Sci. 2010 Apr;2(2):72-9. doi: 10.4103/0975-7406.67003.
10
Phase I/II dose escalation study of angiotensin 1-7 [A(1-7)] administered before and after chemotherapy in patients with newly diagnosed breast cancer.新诊断乳腺癌患者化疗前后给予血管紧张素1-7 [A(1-7)]的I/II期剂量递增研究。
Cancer Chemother Pharmacol. 2006 May;57(5):559-68. doi: 10.1007/s00280-005-0078-4. Epub 2005 Aug 12.

Development of angiotensin II (1-7) analog as an oral therapeutic for the treatment of chemotherapy-induced myelosuppression.

作者信息

Gaffney Kevin, Weinberg Michael, Soto Maira, Louie Stan, Rodgers Kathleen

机构信息

Department of Pharmacology, University of Arizona, Tucson, AZ

Center for Innovation in Brain Science, University of Arizona, Tucson, AZ.

出版信息

Haematologica. 2018 Dec;103(12):e567-e570. doi: 10.3324/haematol.2018.193771. Epub 2018 Jul 5.

DOI:10.3324/haematol.2018.193771
PMID:29976741
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6269317/
Abstract
摘要