Department 1 of General Surgery, The First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
The Institute of General Surgery, The First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
Biosci Rep. 2018 Sep 25;38(5). doi: 10.1042/BSR20180712. Print 2018 Oct 31.
MiRNA polymorphisms had potential to be biomarkers for hepatocellular cancer (HCC) susceptibility. Recently, miRNA single nucleotide polymorphisms (SNPs) were reported to be associated with HCC risk, but the results were inconsistent. We performed a systematic review with a meta-analysis for the association of miRNA SNPs with HCC risk. Thirty-seven studies were included with a total of 11821 HCC patients and 15359 controls in this meta-analysis. We found hsa- rs2910164 was associated with a decreased HCC risk in the recessive model (=0.017, OR = 0.90, 95% confidence interval (CI) = 0.83-0.98). While hsa- rs4938723 was related with an increased HCC risk in the co-dominant model (=0.016, odds ratio (OR) = 1.19, 95%CI = 1.03-1.37). When analyzing the Hepatitis B virus (HBV)-related HCC risk, hsa- rs11614913 was associated with a decreased HBV-related HCC risk in the co-dominant and allelic models. And hsa- rs2292832 was found to be associated with a decreased HBV-related HCC risk in the dominant and recessive models. In conclusion, hsa- rs2910164 and hsa- rs4938723 could be biomarkers for the HCC risk while hsa- rs11614913 and hsa- rs2292832 had potential to be biomarkers for HBV-related HCC risk.
miRNA 多态性有可能成为肝细胞癌 (HCC) 易感性的生物标志物。最近，miRNA 单核苷酸多态性 (SNP) 与 HCC 风险相关的报道，但结果不一致。我们进行了一项系统评价和荟萃分析，以评估 miRNA SNPs 与 HCC 风险的相关性。这项荟萃分析共纳入了 37 项研究，共包括 11821 例 HCC 患者和 15359 例对照。我们发现 hsa-rs2910164 与 HCC 风险降低的隐性模型有关 (=0.017，OR=0.90，95%置信区间（CI）=0.83-0.98)。而 hsa-rs4938723 与 HCC 风险增加的共显性模型有关 (=0.016，比值比（OR）=1.19，95%CI=1.03-1.37)。在分析乙型肝炎病毒（HBV）相关 HCC 风险时，hsa-rs11614913 与 HBV 相关 HCC 风险的共显性和等位基因模型相关。并且发现 hsa-rs2292832 与 HBV 相关 HCC 风险的显性和隐性模型相关。总之，hsa-rs2910164 和 hsa-rs4938723 可能是 HCC 风险的生物标志物，而 hsa-rs11614913 和 hsa-rs2292832 可能是 HBV 相关 HCC 风险的生物标志物。
