Zhou Jian, Liu Yue, Wang Wanchun, Xu Feng-Lei
Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Department of Sports Medicine Research Center, Central South University, Changsha, Hunan 410008, P.R. China.
Mol Clin Oncol. 2018 Jul;9(1):54-57. doi: 10.3892/mco.2018.1617. Epub 2018 Apr 26.
Histiocytic sarcoma (HS) is a term used to describe malignant hyperplasia of cells exhibiting morphological and immunophenotypical characteristics similar to those of mature cells, with expression of one or more tissue cell markers, excluding acute monocytic leukemia and primitive monocytic sarcoma. We herein describe a case of histiocytic sarcoma of the neck supported by histopathological and immunohistological evidence. A 53-year-old female patient of Chinese descent presented with a rapidly enlarging right neck mass. Imaging studies revealed multiple right cervical lymphadenectases with right jugular vein involvement. The tumor was composed of diffusely distributed large non-cohesive tumor cells, round or oval and focally spindle-shaped. The tumor cells were immunopositive for macrophage-associated antigen CD68 and lysosomes, mostly consistent with a diagnosis of HS. HS is very prone to systemic metastasis; therefore, early diagnosis and timely treatment are crucial.
组织细胞肉瘤（HS）是一个用于描述细胞恶性增生的术语，这些细胞表现出与成熟细胞相似的形态学和免疫表型特征，表达一种或多种组织细胞标志物，不包括急性单核细胞白血病和原始单核细胞肉瘤。我们在此描述一例经组织病理学和免疫组织学证据支持的颈部组织细胞肉瘤病例。一名53岁华裔女性患者出现右颈部肿块迅速增大。影像学检查显示右侧多发颈淋巴结肿大并累及右颈静脉。肿瘤由弥漫分布的大的、无黏附性的肿瘤细胞组成，呈圆形或椭圆形，局部呈梭形。肿瘤细胞巨噬细胞相关抗原CD68和溶酶体免疫阳性，大多符合HS诊断。HS极易发生全身转移；因此，早期诊断和及时治疗至关重要。
