Giesler C F, Buehler J H, Depp R
Obstet Gynecol. 1977 Jan;49(1):31-4.
The case of a 37-year-old primigravida with severe obstructive lung disease and alpha1-antitrypsin deficiency is reported. Serial pulmonary function studies and arterial blood gases were obtained during the antenatal and postpartum periods. Intrauterine fetal growth was monitored with serial ultrasonic fetal biparietal diameter determinations. Serial oxytocin challenge tests were used to monitor uteroplacental function. Aggressive chest physiotherapy was used to maintain good maternal bronchopulmonary hygiene. A normal female infant was delivered vaginally at 38 weeks' gestation following an uneventful labor. The available obstetric literature regarding the outcome of pregnancy in patients with obstructive lung disease and cystic fibrosis is reviewed. This literature suggests that pregnancy in a patient with severe obstructive lung disease should be considered a medical indication for therapeutic abortion. Successful delivery of this patient with severe obstructive lung disease and alpha1-antitrypsin deficiency suggests that these conditions are not a contraindication to successful outcome of preganncy for both mother and child.
报道了一例37岁初产妇，患有严重阻塞性肺病和α1 -抗胰蛋白酶缺乏症。在产前和产后期间进行了系列肺功能研究和动脉血气分析。通过系列超声测量胎儿双顶径监测宫内胎儿生长情况。采用系列催产素激惹试验监测子宫胎盘功能。积极的胸部物理治疗用于保持良好的母体支气管肺卫生。经过平稳的分娩过程，孕38周时经阴道分娩出一名正常女婴。回顾了现有关于阻塞性肺病和囊性纤维化患者妊娠结局的产科文献。该文献表明，患有严重阻塞性肺病的患者妊娠应被视为治疗性流产的医学指征。这位患有严重阻塞性肺病和α1 -抗胰蛋白酶缺乏症的患者成功分娩表明，这些情况并非母婴妊娠成功结局的禁忌证。
