Hewitt Jayne E
PhD Candidate, Griffith Law School, Griffith University.
J Law Med. 2018 Apr;25(3):782-793.
Since the human genome was successfully mapped much academic attention has been given to ethical, legal and regulatory issues associated with the integration and application of genomics in health care. In line with the recent political commitment to promoting precision medicine that relies heavily on omic knowledge, it is timely to review the issues that this body of literature has addressed. Focusing on pharmacogenomics, this review quantifies the issues identified in this body of academic work. It reveals that, after nearly two decades, interest in the regulatory and legal issues associated with pharmacogenomics continues to generate significant attention. The ethical issues, while not as predominant, also persist. The analyses highlights that there is a dearth of empirical research exploring the impact that these issues have had.
自人类基因组成功绘制以来，许多学术关注都集中在基因组学在医疗保健中的整合与应用所涉及的伦理、法律和监管问题上。鉴于近期对大力依赖组学知识的精准医学的政治承诺，及时回顾这一系列文献所探讨的问题是很有必要的。本综述聚焦于药物基因组学，对该学术领域所确定的问题进行了量化。结果显示，近二十年来，与药物基因组学相关的监管和法律问题持续引发高度关注。伦理问题虽不那么突出，但也依然存在。分析突出表明，缺乏实证研究来探究这些问题所产生的影响。
