Li Jiu-Rong, Liu Qun, Chen Chun-Cheng, Ma Ai-Ping
Department of Respiratory,the First Hospital Affiliated to Xiamen University,Xiamen,Fujian 361003,China.
Department of Pathology,Zhongshan Hospital Affiliated to Xiamen University,Xiamen,Fujian 361004,China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2018 Jun 28;40(3):334-337. doi: 10.3881/j.issn.1000-503X.2018.03.006.
Objective To explore the association between the severity of scrub typhus (ST) and the serum procalcitonin (PCT) level. Methods The clinical data of 58 ST patients who were treated in the First Affiliated Hospital of Xiamen University and confirmed by Xiamen Municipal Center for Disease Prevention and Control (CDC) from January 2016 to October 2017,were retrospectively analyzed. According to clinical manifestations and related laboratory tests,these patients were divided into four grades:Ⅰ,Ⅱ,Ⅲ,and Ⅳ. These four grade groups were compared in terms of age,interval from symptom onset to hospital presentation,hospitalization days,and serum PCT level. Results These 58 patients were divided into four grade groups:grade Ⅰ group (n=17),grade Ⅱ group (n=17),grade Ⅲ group (n=11),and grade Ⅳ group (n=13). No significant difference was found among these four groups in terms of age (F=0.618,P=0.606),interval from symptom onset to hospital presentation (F=1.744,P=0.169),and hospitalization days (F=0.398,P=0.755).However,the median serum PCT level in the grade Ⅳ patients[2.60(1.33,61.08)ng/ml] was significantly higher than those in grade I[0.24(0.10,0.33)ng/ml;Z=-4.63,P=0.000], grade Ⅱ[0.29(0.21,0.51)ng/ml;Z=-4.63,P=0.000], and grade Ⅲ[1.33(0.89,2.41)ng/ml;Z=-2.09,P=0.040].The median serum PCT level in the grade Ⅲ patients was also significantly higher than grade Ⅰ (Z=-4.16,P=0.000)and grade Ⅱ(Z=-3.83,P=0.000).There was no significant difference between the grade Ⅰ patients and grade Ⅱ patients(Z=-1.37,P=0.170).There was significantly positive correlation between PCT level and the severity of ST (r=0.804,P=0.000).Conclusion There is positive correlation between serum PCT level and the severity of ST,and serum PCT level may be a biomarker in assessing the severity of ST.
目的 探讨恙虫病（ST）严重程度与血清降钙素原（PCT）水平之间的关联。方法 回顾性分析2016年1月至2017年10月在厦门大学附属第一医院治疗并经厦门市疾病预防控制中心（CDC）确诊的58例ST患者的临床资料。根据临床表现及相关实验室检查，将这些患者分为Ⅰ、Ⅱ、Ⅲ、Ⅳ四个等级。比较这四个等级组在年龄、症状出现至入院间隔时间、住院天数及血清PCT水平方面的差异。结果 这58例患者分为四个等级组：Ⅰ级组（n = 17）、Ⅱ级组（n = 17）、Ⅲ级组（n = 11）和Ⅳ级组（n = 13）。这四组在年龄（F = 0.618，P = 0.606）、症状出现至入院间隔时间（F = 1.744，P = 0.169）和住院天数（F = 0.398，P = 0.755）方面差异均无统计学意义。然而，Ⅳ级患者血清PCT水平中位数[2.60（1.33，61.08）ng/ml]显著高于Ⅰ级[0.24（0.10，0.33）ng/ml；Z = -4.63，P = 0.000]、Ⅱ级[0.29（0.21，0.51）ng/ml；Z = -4.63，P = 0.000]和Ⅲ级[1.33（0.89，2.41）ng/ml；Z = -2.09，P = 0.040]患者。Ⅲ级患者血清PCT水平中位数也显著高于Ⅰ级（Z = -4.16，P = 0.000）和Ⅱ级（Z = -3.83，P = 0.000）患者。Ⅰ级患者和Ⅱ级患者之间差异无统计学意义（Z = -1.37，P = 0.170）。PCT水平与ST严重程度呈显著正相关（r = 0.804，P = 0.000）。结论 血清PCT水平与ST严重程度呈正相关，血清PCT水平可能是评估ST严重程度的生物标志物。
