a Department of Hematology , Wroclaw Medical University , Wrocław , Poland.
b Faculty of Mathematics and Information Science , Warsaw University of Technology , Warsaw , Poland.
Leuk Lymphoma. 2019 Feb;60(2):341-348. doi: 10.1080/10428194.2018.1482539. Epub 2018 Jul 6.
We retrospectively analyzed long-term disease outcome of 350 elderly Hodgkin Lymphoma (eHL) patients treated with ABVD/ABVD-like regimen enrolled in the PLRG-R9 study between 2001 and 2013 in Poland. Complete remission was reported for 73% of early (ES) and 61% advanced stage (AS) patients. Nine (10%) ES and 56 (20%) AS patients have died. With the median follow-up of 36 (1-190) months, 3-year EFS and OS was 0.74 (95%CI: 0.63-0.85) and 0.90 (95%CI: 0.82-0.98) for ES; 0.51 (95%CI: 0.44-0.57), and 0.81 (95%CI: 0.75-0.86) for AS patients, respectively. For ES patients, Cox regression revealed ECOG <2 and age >70 as predictive for inferior OS and EFS. For AS patients, the most predictive for OS was the presence of cardiovascular disorders (CVD) (p = .00044), while for EFS four factors were significantly associated with a poor outcome: ECOG< 2, age >70 years, CVD and extranodal disease. In conclusion, CVD significantly impacts outcomes of ABVD-treated advanced eHL patients.
我们回顾性分析了 2001 年至 2013 年期间在波兰的 PLRG-R9 研究中接受 ABVD/ABVD 样方案治疗的 350 例老年霍奇金淋巴瘤（eHL）患者的长期疾病结局。早期（ES）和晚期（AS）患者的完全缓解率分别为 73%和 61%。9 例 ES 和 56 例 AS 患者死亡。中位随访 36（1-190）个月后，ES 患者的 3 年 EFS 和 OS 分别为 0.74（95%CI：0.63-0.85）和 0.90（95%CI：0.82-0.98）；AS 患者分别为 0.51（95%CI：0.44-0.57）和 0.81（95%CI：0.75-0.86）。对于 ES 患者，Cox 回归显示 ECOG <2 和年龄>70 是 OS 和 EFS 不良的预测因素。对于 AS 患者，最能预测 OS 的是心血管疾病（CVD）的存在（p = .00044），而对于 EFS，四个因素与不良预后显著相关：ECOG<2、年龄>70 岁、CVD 和结外疾病。总之，CVD 显著影响 ABVD 治疗的晚期 eHL 患者的结局。
