Ljungman P, Lönnqvist B, Wahren B, Ringdén O, Gahrton G
Transplantation. 1985 Nov;40(5):515-20. doi: 10.1097/00007890-198511000-00009.
A group of 46 bone marrow transplant (BMT) recipients were studied by lymphocyte stimulation with cytomegalovirus (CMV) antigen before, and repeatedly in the first year after, BMT. Of these, 25 patients developed CMV infection and 68% of these got a positive lymphocyte response to CMV. The recipients with an early response (up to 3 months) to CMV antigen after the CMV infection were less prone to develop chronic graft-versus-host disease (GVHD) than those who responded later or not at all (P = 0.002). After the CMV infection, the increased lymphocyte CMV reactivity remained in recipients without chronic GVHD, but recipients with chronic GVHD usually lost their reactivity. The results suggest that it may be possible to predict patients who are not going to develop chronic GVHD by studying lymphocyte responses to CMV infections.
一组46名骨髓移植（BMT）受者在BMT前及BMT后的第一年多次接受巨细胞病毒（CMV）抗原刺激淋巴细胞研究。其中，25名患者发生了CMV感染，这些患者中有68%对CMV的淋巴细胞反应呈阳性。CMV感染后对CMV抗原早期（至3个月）有反应的受者比那些反应较晚或根本无反应的受者更不易发生慢性移植物抗宿主病（GVHD）（P = 0.002）。CMV感染后，无慢性GVHD的受者淋巴细胞CMV反应性增加，但有慢性GVHD的受者通常失去反应性。结果表明，通过研究淋巴细胞对CMV感染的反应，有可能预测哪些患者不会发生慢性GVHD。
