Ganelina L Sh
Tsitologiia. 1985 Aug;27(8):851-64.
Literary data are reviewed on the role of the cAMP-dependent phosphorylation of proteins in the regulation of cell metabolism, membrane permeability, and muscle contraction. It is suggested that a low cAMP level in the tumor and other actively proliferating cells may be associated with a raised exit of cAMP from cells into the surrounding medium because of the increased phosphorylation of the membrane proteins of these cells.
本文综述了有关蛋白质的环磷酸腺苷(cAMP)依赖性磷酸化在细胞代谢、膜通透性和肌肉收缩调节中的作用的文献资料。研究表明,肿瘤细胞和其他活跃增殖细胞中cAMP水平较低,可能是由于这些细胞的膜蛋白磷酸化增加,导致cAMP从细胞内大量排出到周围介质中。