Konijnenberg Carolien, Jondalen Nils Martin, Husby Mikael Falkhaugen, Melinder Annika
a Department of Psychology , Inland Norway University of Applied Sciences , Lillehammer , Norway.
b Cognitive Developmental Research Unit, Department of Psychology , University of Oslo , Oslo , Norway.
Dev Neuropsychol. 2018;43(7):642-655. doi: 10.1080/87565641.2018.1493592. Epub 2018 Jul 6.
Much is still unknown about the potential long-term effects of prenatal methadone and buprenorphine exposure. We examined neural correlates of cognitive control in 19 prenatally methadone and buprenorphine exposed and 21 nondrug exposed children, aged 9-11 years. Children performed a modified version of the Eriksen Flanker task, which taps into selective attention, conflict response, and response inhibition mechanisms. We investigated behavioral responses and the ERP components N1, P2, N2, P3, and the late positive component (LPC). Children in the exposed group showed normal cognitive control function. However, an atypical ERP response related to perceptual and attention allocation processes was found in the exposed group.
关于产前接触美沙酮和丁丙诺啡的潜在长期影响，仍有许多未知之处。我们对19名产前接触美沙酮和丁丙诺啡的儿童以及21名未接触药物的9至11岁儿童进行了认知控制的神经关联研究。儿童进行了改良版的埃里克森侧翼任务，该任务涉及选择性注意、冲突反应和反应抑制机制。我们研究了行为反应以及ERP成分N1、P2、N2、P3和晚期正成分（LPC）。暴露组儿童表现出正常的认知控制功能。然而，在暴露组中发现了与感知和注意力分配过程相关的非典型ERP反应。
