增强子衍生的 RNA 肌动蛋白调节 Myogenin 的反式作用。

An Enhancer-Derived RNA Muscles In to Regulate Myogenin In trans.

机构信息

Blizard Institute, Barts and The London School of Medicine and Dentistry, QMUL, London E1 2AT, UK; School of Biological Sciences, University of Essex, Colchester CO4 3SQ, UK.

出版信息

Mol Cell. 2018 Jul 5;71(1):3-5. doi: 10.1016/j.molcel.2018.06.024.

DOI:10.1016/j.molcel.2018.06.024

PMID:29979967

Abstract

Noncoding RNAs (ncRNAs) transcribed from active enhancers are known as enhancer RNAs (eRNAs). eRNAs have generally been shown to contribute to transcriptional activation of target genes in cis. In this issue, Tsai et al. (2018) demonstrate that an eRNA expressed from a distal enhancer of Myogenic differentiation1 (MyoD) (eRNA) does not regulate its neighboring MyoD; instead, it promotes myogenic differentiation by activating Myogenin, which is located on a different chromosome.

摘要

非编码 RNA（ncRNA）转录自活性增强子，被称为增强子 RNA（eRNA）。一般来说，eRNA 被认为有助于顺式转录激活靶基因。在本期中，Tsai 等人（2018）证明了来自肌分化 1（MyoD）的远端增强子的 eRNA（eRNA）不调节其邻近的 MyoD；相反，它通过激活位于不同染色体上的 Myogenin 来促进成肌分化。