帕金森病中的 Th17 细胞：中脑之患。
Th17 Cells in Parkinson's Disease: The Bane of the Midbrain.
机构信息
Center for Brain Immunology and Glia (BIG), Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA; Medical Scientist Training Program, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Center for Brain Immunology and Glia (BIG), Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA; Graduate Program in Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
出版信息
Cell Stem Cell. 2018 Jul 5;23(1):5-6. doi: 10.1016/j.stem.2018.06.016.
Abstract
Emerging data implicate potential roles for T cells in Parkinson's disease (PD); however, direct evidence for human T cells in PD-associated neurodegeneration has been lacking. In this issue of Cell Stem Cell, Sommer et al. (2018) demonstrate that IL-17-producing T cells from sporadic PD patients promote cell death of patient iPSC-derived midbrain neurons.
摘要
新出现的数据表明 T 细胞可能在帕金森病（PD）中发挥作用；然而，直接证明 T 细胞在 PD 相关神经退行性变中的作用一直缺乏。在本期《Cell Stem Cell》中，Sommer 等人（2018）证明了来自散发性 PD 患者的产生白介素-17 的 T 细胞促进了患者诱导多能干细胞来源的中脑细胞死亡。
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本文引用的文献
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T cells from patients with Parkinson's disease recognize α-synuclein peptides.帕金森病患者的T细胞可识别α-突触核蛋白肽段。
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Th17 Cells Induce Dopaminergic Neuronal Death via LFA-1/ICAM-1 Interaction in a Mouse Model of Parkinson's Disease.Th17 细胞通过 LFA-1/ICAM-1 相互作用在帕金森病小鼠模型中诱导多巴胺能神经元死亡。
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