帕金森病患者的T细胞可识别α-突触核蛋白肽段。
T cells from patients with Parkinson's disease recognize α-synuclein peptides.
作者信息
Sulzer David, Alcalay Roy N, Garretti Francesca, Cote Lucien, Kanter Ellen, Agin-Liebes Julian, Liong Christopher, McMurtrey Curtis, Hildebrand William H, Mao Xiaobo, Dawson Valina L, Dawson Ted M, Oseroff Carla, Pham John, Sidney John, Dillon Myles B, Carpenter Chelsea, Weiskopf Daniela, Phillips Elizabeth, Mallal Simon, Peters Bjoern, Frazier April, Lindestam Arlehamn Cecilia S, Sette Alessandro
机构信息
Departments of Psychiatry, Columbia University, Division of Molcular Therapeutics, New York State Psychiatric Institute, New York, New York 10032, USA.
Department of Neurology, Columbia University, New York, New York 10032, USA.
出版信息
Nature. 2017 Jun 29;546(7660):656-661. doi: 10.1038/nature22815. Epub 2017 Jun 21.
Genetic studies have shown the association of Parkinson's disease with alleles of the major histocompatibility complex. Here we show that a defined set of peptides that are derived from α-synuclein, a protein aggregated in Parkinson's disease, act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in patients with Parkinson's disease. These responses may explain the association of Parkinson's disease with specific major histocompatibility complex alleles.
基因研究表明帕金森病与主要组织相容性复合体的等位基因有关联。在此我们表明，一组特定的、源自α-突触核蛋白（一种在帕金森病中聚集的蛋白质）的肽，可作为由这些等位基因呈现的抗原表位，并在帕金森病患者中引发辅助性T细胞和细胞毒性T细胞反应。这些反应可能解释了帕金森病与特定主要组织相容性复合体等位基因之间的关联。
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