子宫内膜异位症中 sonic hedgehog 信号通路的异常激活及其诊断效力。
Abnormal activation of the sonic hedgehog signaling pathway in endometriosis and its diagnostic potency.
机构信息
Department of Gynecology, the First Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China.
The First Hospital of Harbin, Harbin, People's Republic of China.
出版信息
Fertil Steril. 2018 Jul 1;110(1):128-136.e2. doi: 10.1016/j.fertnstert.2018.02.138.
OBJECTIVE
To investigate the abnormal expression of sonic hedgehog (SHH) signaling molecules in 52 eutopic endometrial tissues and its diagnostic potency in endometriosis.
DESIGN
Retrospective study.
SETTING
University hospital.
PATIENT(S): Twenty-six women with histologically confirmed endometriosis and 26 women with histologically normal endometria who were undergoing curettage or hysterectomy were selected.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): The mRNA and protein levels of molecules in the SHH signaling pathway.
RESULT(S): The levels of SHH, smoothened, GLI family zinc finger 3, and its downstream signaling transcription factor (GLI1) not only were upregulated in the eutopic endometrium of endometriosis compared with the control endometrium, but also independently predicted the onset and severity of the disease.
CONCLUSION(S): This study is the first to reveal differences in the activation of the SHH signaling pathway between women with and without endometriosis and suggests that the SHH signaling pathway has potential in the diagnosis of endometriosis.
目的
研究 sonic hedgehog（SHH）信号分子在 52 份在位子宫内膜组织中的异常表达及其在子宫内膜异位症中的诊断价值。
设计
回顾性研究。
地点
大学医院。
患者
选择了 26 名经组织学证实患有子宫内膜异位症的妇女和 26 名接受刮宫术或子宫切除术的组织学正常的妇女。
干预措施
无。
主要观察指标
SHH 信号通路中分子的 mRNA 和蛋白水平。
结果
与对照组子宫内膜相比，子宫内膜异位症患者在位子宫内膜中 SHH、 smoothened、GLI 家族锌指蛋白 3 及其下游信号转导转录因子（GLI1）的水平不仅上调，而且独立预测疾病的发生和严重程度。
结论
本研究首次揭示了子宫内膜异位症患者和非子宫内膜异位症患者之间 SHH 信号通路激活的差异，并表明 SHH 信号通路在子宫内膜异位症的诊断中有一定的潜力。
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