Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Johns Hopkins University, Lutherville, Maryland.
The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College, New York, New York.
Fertil Steril. 2018 Jul 1;110(1):14-18. doi: 10.1016/j.fertnstert.2018.04.011.
In commemoration of 40 years of in vitro fertilization (IVF), herein we describe the early evolution of the first IVF program at the Eastern Virginia Medical School in Norfolk, Virginia. The birth of the first American IVF baby was the result of the work of many investigators, both in experimental animal models and in humans, heavily relying on the experience of Robert Edwards and Patrick Steptoe in Great Britain. Although their first IVF baby was the result of the retrieval of a single oocyte in the natural cycle, duplicating their methods was not successful in Norfolk. It turns out that the achievement of the first pregnancy in the United States was associated with introducing ovarian stimulation with gonadotropins, establishing the appropriate timing for egg retrieval after hCG administration, retrieving multiple mature oocytes, determining the ideal time for in vitro insemination, and optimizing embryo culture media.
为纪念体外受精（IVF） 40 周年，本文描述了弗吉尼亚州诺福克市东弗吉尼亚医学院首例 IVF 项目的早期发展历程。首例美国 IVF 婴儿的诞生是许多研究人员的工作成果，他们的研究既有实验动物模型，也有针对人类的研究，很大程度上依赖于英国的罗伯特·爱德华兹和帕特里克·斯特普托的经验。尽管他们的首例 IVF 婴儿是从自然周期中取出单个卵子的结果，但在诺福克复制他们的方法并不成功。事实证明，美国首例妊娠的成功与引入促性腺激素进行卵巢刺激、确定 hCG 给药后取卵的适当时机、取出多个成熟卵子、确定体外授精的理想时间以及优化胚胎培养液有关。
