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子宫移植:供体死亡模型中的器官获取。

Uterus transplantation: organ procurement in a deceased donor model.

机构信息

Department of Obstetrics and Gynecology, Cleveland Clinic, Cleveland, Ohio.

Department of Obstetrics and Gynecology, Cleveland Clinic, Cleveland, Ohio.

出版信息

Fertil Steril. 2018 Jul 1;110(1):183. doi: 10.1016/j.fertnstert.2018.04.014.

DOI:10.1016/j.fertnstert.2018.04.014
PMID:29980257
Abstract

OBJECTIVE

To demonstrate our technique of uterine procurement from a deceased donor.

DESIGN

This video uses live action footage from surgery and detailed illustrations to review the steps and techniques involved in deceased donor procurement surgery.

SETTING

Academic medical center.

PATIENT(S): A deceased multiorgan donor.

INTERVENTION(S): Trial organ procurement of a viable uterus from a deceased donor.

MAIN OUTCOME MEASURE(S): Procurement time and associated features of suitability of dissected specimen.

RESULT(S): This video article describes the advantages of a deceased donor model over a live donor model, including eliminating the risk of surgical complications to a living donor, avoidance of ethical issues inherent in live donation, easier access to generous vascular pedicles for anastomosis, and faster procurement time. This video also outlines the key steps to a successful uterine procurement using illustrations and live action footage from a trial organ procurement.

CONCLUSION(S): Uterine transplantation is an emerging surgical treatment for patients with absolute uterine factor infertility. Continued practice is essential in preparing for a deceased donor uterine procurement. The process continues to be refined and adapted as new information becomes available toward the goal of safe, efficient, ethical, and effective surgical treatment of absolute uterine factor infertility.

摘要

目的

展示从已故供体获取子宫的技术。

设计

本视频采用手术现场录像和详细插图,回顾了已故供体获取手术中涉及的步骤和技术。

地点

学术医疗中心。

患者

已故多器官供体。

干预措施

从已故供体中尝试获取可行的子宫。

主要观察指标

获取时间和解剖标本的适宜性相关特征。

结果

本视频文章介绍了已故供体模型相对于活体供体模型的优势,包括消除活体供体手术并发症的风险、避免活体捐赠固有的伦理问题、更容易获得用于吻合的丰富血管蒂,以及更快的获取时间。本视频还通过来自一次尝试性器官获取的现场录像和插图,概述了成功获取子宫的关键步骤。

结论

子宫移植是治疗绝对子宫因素不孕的新兴手术治疗方法。继续实践对于准备进行已故供体子宫获取至关重要。随着新信息的不断出现,该过程不断得到改进和调整,以实现安全、高效、符合伦理且有效的绝对子宫因素不孕的手术治疗。

相似文献

1
Uterus transplantation: organ procurement in a deceased donor model.子宫移植:供体死亡模型中的器官获取。
Fertil Steril. 2018 Jul 1;110(1):183. doi: 10.1016/j.fertnstert.2018.04.014.
2
Deceased donor uterus retrieval: A novel technique and workflow.供体子宫切除术:一种新的技术和工作流程。
Am J Transplant. 2018 Mar;18(3):679-683. doi: 10.1111/ajt.14476. Epub 2017 Sep 23.
3
Deceased donor uterine transplantation.已故捐赠者子宫移植
Fertil Steril. 2017 Mar;107(3):e13. doi: 10.1016/j.fertnstert.2016.12.009. Epub 2017 Feb 8.
4
Revaluation and lessons learned from the first 9 cases of a Czech uterus transplantation trial: Four deceased donor and 5 living donor uterus transplantations.捷克首例 9 例子宫移植试验的再评估及经验教训:4 例尸肾供体和 5 例活体供体子宫移植。
Am J Transplant. 2019 Mar;19(3):855-864. doi: 10.1111/ajt.15096. Epub 2018 Oct 9.
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Uterus procurement from deceased donor for transplantation.从已故供体获取子宫用于移植。
Transpl Int. 2021 Dec;34(12):2570-2577. doi: 10.1111/tri.14143. Epub 2021 Nov 10.
6
Techniques for successful vaginal anastomosis in the uterine transplantation patient.成功进行子宫移植患者阴道吻合术的技术。
Fertil Steril. 2021 Mar;115(3):802-803. doi: 10.1016/j.fertnstert.2020.05.017. Epub 2020 Jul 16.
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Uterus transplantation:robotic surgeon perspective.子宫移植:机器人外科医生视角。
Fertil Steril. 2018 Feb;109(2):365. doi: 10.1016/j.fertnstert.2017.10.038. Epub 2017 Dec 13.
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Uterus Transplantation: The Ethics of Using Deceased Versus Living Donors.子宫移植:使用已故供体与活体供体的伦理问题。
Am J Bioeth. 2018 Jul;18(7):6-15. doi: 10.1080/15265161.2018.1478018.
9
Deceased donor availability for uterus transplantation in Australia.澳大利亚可供子宫移植使用的已故供体情况。
Aust N Z J Obstet Gynaecol. 2023 Dec;63(6):780-785. doi: 10.1111/ajo.13722. Epub 2023 Jul 3.
10
Clinical pregnancy after deceased donor uterus transplantation: Lessons learned and future perspectives.已故供体子宫移植后的临床妊娠:经验教训与未来展望。
J Obstet Gynaecol Res. 2019 Aug;45(8):1458-1465. doi: 10.1111/jog.13992. Epub 2019 May 6.

引用本文的文献

1
Deceased Donor Uterus Transplantation: A Narrative Review of the First 24 Published Cases.已故供体子宫移植:24 例已发表病例的叙述性综述。
Medicina (Kaunas). 2024 Aug 19;60(8):1348. doi: 10.3390/medicina60081348.
2
Systematic Sampling of the Female Reproductive System for Molecular Characterization.女性生殖系统的系统采样用于分子特征分析。
Curr Protoc. 2023 Aug;3(8):e848. doi: 10.1002/cpz1.848.
3
Graft Failure after Uterus Transplantation in 16 Recipients: A Review.16例子宫移植受者术后移植物失败:一项综述
J Clin Med. 2023 Mar 3;12(5):2032. doi: 10.3390/jcm12052032.
4
Uterus Transplantation: Revisiting the Question of Deceased Donors versus Living Donors for Organ Procurement.子宫移植:重新审视器官获取中 deceased 供体与活体供体的问题。 (注:这里“deceased”直译为“已故的”,在医学语境中可理解为“死亡的”供体 )
J Clin Med. 2022 Aug 3;11(15):4516. doi: 10.3390/jcm11154516.
5
Uterus transplantation: state of the art in 2021.子宫移植:2021 年的最新进展。
J Assist Reprod Genet. 2021 Sep;38(9):2251-2259. doi: 10.1007/s10815-021-02245-7. Epub 2021 May 31.
6
Uterus Transplantation with Live Donors: Screening Candidates in One French Center.活体供体子宫移植:法国一家中心的候选者筛选
J Clin Med. 2020 Jun 25;9(6):2001. doi: 10.3390/jcm9062001.