在全国严重联合免疫缺陷症新生儿筛查计划中，对 HIV 暴露但未感染的新生儿进行 T 细胞受体切除环测量。
T-Cell Receptor Excision Circles in HIV-Exposed, Uninfected Newborns Measured During a National Newborn Screening Program for Severe Combined Immunodeficiency.
机构信息
Institut National de la Santé et de la Recherche Médicale (INSERM) CESP U1018, Centre de Recherche en Epidémiologie et Santé des Populations, Le Kremlin-Bicêtre, France; Assistance Publique-Hôpitaux de Paris (AP-HP), Service d'Epidémiologie et de Santé Publique, Hôpitaux Universitaires Paris Sud, Hôpital Bicêtre, Le Kremlin-Bicêtre, France; Université Paris Sud/Paris-Saclay, Le Kremlin-Bicêtre, France.
Service d'Hématologie oncologie et immunologie pédiatriques, Hôpital Mère-Enfant, Centre Hospitalo-Universitaire (CHU), Nantes, France.
出版信息
J Pediatr. 2018 Nov;202:311-314.e2. doi: 10.1016/j.jpeds.2018.06.008. Epub 2018 Jul 3.
Severe combined immunodeficiency screening by measuring T-receptor excision circles at birth allows evaluation of the impact of various maternal conditions on newborn immunity. The slight decrease observed in a French cohort of newborns to HIV-infected mothers can be explained by the confounding factors of prematurity and African descent.
通过测量出生时的 T 受体切除环来进行严重联合免疫缺陷筛查，可以评估各种母体状况对新生儿免疫力的影响。在感染 HIV 的法国母亲所生的新生儿队列中观察到的轻微下降，可以用早产和非洲裔的混杂因素来解释。
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