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[放射治疗在小细胞肺癌患者治疗中的作用]

[Role of radiation therapy in the treatment of patients with small cell lung cancer].

作者信息

Kiseleva E S, Dar'ialova S L, Boĭko A V, Zvekotkina L S

出版信息

Vopr Onkol. 1985;31(10):55-61.

PMID:2998091
Abstract

The paper presents a review of up-to-date literature on the problems of morphological heterogeneity of small cell lung cancer, clinico-morphological parallels, main prognostic factors and rationale for application of radiation therapy in the complex treatment of the disease. The authors also discuss their own findings on 208 cases, with 170 of them having localized tumor. Superfractionated irradiation of a locoregional zone with 1.2 Gy thrice a day was conducted at the initial stage of treatment (total dose--46.8 Gy). As a result, complete regression was obtained in 65.5% and partial regression in 34.5%. All patients with localized tumor survived six months after radiation chemotherapy, 58.5%--12 months, and 57.1%--24 months.

摘要

本文对小细胞肺癌形态学异质性问题、临床形态学相似性、主要预后因素以及放射治疗在该疾病综合治疗中的应用原理的最新文献进行了综述。作者还讨论了他们对208例病例的自身研究结果,其中170例为局限性肿瘤。在治疗初期,对局部区域进行超分割照射,每天3次,每次1.2 Gy(总剂量 - 46.8 Gy)。结果,65.5%获得完全缓解,34.5%获得部分缓解。所有局限性肿瘤患者在放化疗后存活6个月的比例为100%,存活12个月的比例为58.5%,存活24个月的比例为57.1%。

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