Laboratory of Molecular Pathology, Institute of Biological Sciences (ICB), Federal University of Goiás (UFG), Goiânia, GO, Brazil.
School of Agronomy, Federal University of Goiás (UFG), Goiânia, GO, Brazil.
Mol Cell Endocrinol. 2018 Dec 15;478:10-16. doi: 10.1016/j.mce.2018.07.001. Epub 2018 Jul 5.
Diabetic patients often develop Diabetic Nephropathy (DN) despite severe long-lasting hyperglycemia, while others develop DN even under intensive insulin therapy. This indicates that factors other than chronic hyperglycemia may also contribute to the susceptibility to the development of DN. The purpose of this case-control study was to investigate the possible role of GSTM1 and GSTT1 deletion polymorphisms, and Single Nucleotide Polymorphism (SNP), GSTP1 313 A > G (Ile105Val), in DN susceptibility. Multiple logistic regression analysis revealed that the occurrence of GST polymorphisms in the Central Brazilian population was not associated with increased risk of DN. However, the presence GSTT1 null genotype suggest an increase trend in systolic blood pressure and opposite inference was observed for the GSTP1 genotype (Ile⁄Val or Val⁄Val). On the order hand, other studies may clarify the relationship of these polymorphisms with DN and help in the prevention of this disease.
糖尿病患者尽管存在严重且持久的高血糖，但仍经常发生糖尿病肾病 (DN)，而其他患者即使在强化胰岛素治疗下也会发生 DN。这表明除了慢性高血糖之外，其他因素也可能导致 DN 的易感性。本病例对照研究旨在探讨 GSTM1 和 GSTT1 缺失多态性和单核苷酸多态性 (SNP)、GSTP1 313 A > G (Ile105Val) 与 DN 易感性的可能作用。多因素逻辑回归分析显示，巴西中部人群 GST 多态性的发生与 DN 风险增加无关。然而，GSTT1 缺失基因型的存在提示收缩压呈上升趋势，而 GSTP1 基因型（Ile⁄Val 或 Val⁄Val）则观察到相反的推断。另一方面，其他研究可能会阐明这些多态性与 DN 的关系，并有助于预防这种疾病。
