Telford G L, Hoshmonai M, Moses A J, Szurszewski J H
Am J Physiol. 1985 Nov;249(5 Pt 1):G557-62. doi: 10.1152/ajpgi.1985.249.5.G557.
The role of peripheral and central opioid receptors in morphine-induced migrating myoelectric complexes (MMECs) was studied in conscious dogs implanted with silver-silver chloride electrodes. In normal fasted dogs morphine (100-200 micrograms/kg iv) initiated phase III of the MMEC in the duodenum. Once initiated the MMEC propagated distally. This effect of morphine was blocked by the opioid receptor antagonists naloxone (2 mg/kg iv) and N,N-diallylnormorphinium bromide (4 mg/kg iv). Higher doses of morphine (300-600 micrograms/kg iv) initiated phase III activity in fed dogs as early as 20 min after feeding, while lower doses (150 micrograms/kg iv) initiated phase III activity routinely when administered 100 min after feeding. In dogs with bilateral vagotomies and bilateral thoracolumbar sympathetic chain ganglionectomies, morphine (150 micrograms/kg iv) initiated phase III activity in the duodenum, which then migrated distally. This study demonstrates that morphine initiates phase III of the MMEC by acting through peripheral opioid receptors.
在植入银 - 氯化银电极的清醒犬中，研究了外周和中枢阿片受体在吗啡诱导的移行性肌电复合波（MMECs）中的作用。在正常禁食犬中，静脉注射吗啡（100 - 200微克/千克）可启动十二指肠中MMEC的Ⅲ期。一旦启动，MMEC向远端传播。吗啡的这种作用被阿片受体拮抗剂纳洛酮（静脉注射2毫克/千克）和N，N - 二烯丙基去甲吗啡溴化物（静脉注射4毫克/千克）阻断。更高剂量的吗啡（静脉注射300 - 600微克/千克）在喂食后20分钟内即可在喂食犬中启动Ⅲ期活动，而较低剂量（静脉注射150微克/千克）在喂食后100分钟给药时通常会启动Ⅲ期活动。在双侧迷走神经切断术和双侧胸腰交感链神经节切除术的犬中，静脉注射吗啡（150微克/千克）可启动十二指肠中的Ⅲ期活动，然后向远端迁移。本研究表明，吗啡通过作用于外周阿片受体来启动MMEC的Ⅲ期。
