Department of Public Health, Brooks College of Health, University of North Florida, 1 UNF Drive, Jacksonville, FL 32224, USA.
Department of Public Health, Brooks College of Health, University of North Florida, 1 UNF Drive, Jacksonville, FL 32224, USA.
Environ Res. 2018 Oct;166:588-594. doi: 10.1016/j.envres.2018.06.041. Epub 2018 Jun 30.
To explore the association between polycyclic aromatic hydrocarbons (PAHs) and diabetes and to determine whether effects are heterogeneous when examined by body mass index (BMI).
Cross-sectional data from 8664 participants were analyzed from the National Health and Nutrition Examination Survey for years 2005-2014. Multivariable logistic regression was used to explore the association between urinary biomarkers of PAHs and diabetes. All models were adjusted for age, sex, race, poverty-income ratio, and serum cotinine.
When compared with the lowest quintiles of exposure, the highest quintiles of exposure to 2-hydroxynaphthalene, 2-hydroxyfluorene, 9-hydroxyfluorene, 2-hydroxyphenanthrene, and a summed variable of all low molecular weight PAHs (aOR = 1.73; 95% CI: 1.17-2.55) showed a positive association with diabetes. Stratified analyses by BMI indicated that the positive association between PAHs and diabetes was found among both normal weight and obese participants.
High levels of exposure to PAHs are positively associated with diabetes in the U.S. general population and these effects are modified by BMI. These findings suggest the importance of strong environmental regulation of PAHs to protect population health.
探讨多环芳烃（PAHs）与糖尿病之间的关联，并确定当按体重指数（BMI）进行检查时，这些影响是否存在异质性。
对 2005 年至 2014 年国家健康和营养调查的 8664 名参与者进行了横断面数据分析。多变量逻辑回归用于探讨 PAHs 尿生物标志物与糖尿病之间的关系。所有模型均经过年龄、性别、种族、贫困收入比和血清可替宁调整。
与最低五分位数暴露相比，最高五分位数暴露于 2-羟萘、2-羟基芴、9-羟基芴、2-羟基菲和所有低分子量 PAHs 的总和变量（aOR=1.73；95%CI：1.17-2.55）与糖尿病呈正相关。按 BMI 分层分析表明，PAHs 与糖尿病之间的正相关关系在正常体重和肥胖参与者中均存在。
美国一般人群中高水平的 PAHs 暴露与糖尿病呈正相关，这些影响受 BMI 调节。这些发现表明，需要对 PAHs 进行强有力的环境监管，以保护人群健康。
