Jaime-Pérez José C, Vázquez-Hernández Karina E, Jiménez-Castillo Raúl A, Fernández Lucía T, Salazar-Riojas Rosario, Gómez-Almaguer David
Department of Hematology, Dr José Eleuterio González University Hospital, School of Medicine of the Universidad Autónoma de Nuevo León, Monterrey, México.
Am J Clin Pathol. 2018 Jul 31;150(3):267-272. doi: 10.1093/ajcp/aqy052.
To compare the performance of the corrected count increment (CCI) and three other formulas to assess 24-hour posttransfusion platelet survival in hematology patients.
Twenty-four-hour posttransfusion platelet counts were analyzed after apheresis platelet transfusion. Platelet increment (PI), percent platelet recovery (PPR), and percentage platelet increment (PPI) were compared with CCI by receiver operating characteristic analysis. Clinical factors that influence platelet survival were assessed by logistic regression.
In total, 142 apheresis platelet transfusions in 85 hematology patients were studied. Mean (SD) CCI at 24 hours was 11,869 (10,125). Compared with CCI, the sensitivity of other formulas ranged from 89.4% to 95.7% and specificity from 94.7% to 100%. Cutoff values were 15.7 × 103/µL for PI, 11.4% for PPR, and 17% for PPI. For ABO-compatible vs incompatible transfusions, CCI was 14,070/µL vs 9,176/µL (P = .007). Negative factors for all formulas were sepsis, hypotension, and amphotericin B.
PI, PPR, and PPI are comparable to CCI for assessing 24-hour platelet survival.
比较校正计数增加值（CCI）和其他三个公式评估血液学患者输血后24小时血小板存活率的性能。
对单采血小板输血后的输血后24小时血小板计数进行分析。通过受试者工作特征分析，将血小板增加值（PI）、血小板回收率（PPR）和血小板增加百分比（PPI）与CCI进行比较。通过逻辑回归评估影响血小板存活的临床因素。
共研究了85例血液学患者的142次单采血小板输血。24小时时平均（标准差）CCI为11,869（10,125）。与CCI相比，其他公式的敏感性为89.4%至95.7%，特异性为94.7%至100%。PI的临界值为15.7×10³/µL，PPR为11.4%，PPI为17%。对于ABO血型相合与不相合输血，CCI分别为14,070/µL和9,176/µL（P = 0.007）。所有公式的负面因素为脓毒症、低血压和两性霉素B。
PI、PPR和PPI在评估24小时血小板存活率方面与CCI相当。
