Holguín Luisa, Gallego-Yépes Carolina, Toro Yuliana, Díez-Zuluaga Libia Susana, Mopan José, Chinchilla Carlos
Universidad de Antioquía, Facultad de Medicina, Grupo de Alergología Clínica Experimental, Medellín, Colombia.
Rev Alerg Mex. 2018 Apr-Jun;65(2):148-159. doi: 10.29262/ram.v65i2.354.
Eosinophilic gastrointestinal disorders (EGID) are uncommon. In Colombia there are no studies in the pediatric population.
To describe the epidemiological, clinical and diagnostic characteristics of a pediatric population with EGID.
Observational, retrospective study in children aged between 0 and 12 years, assessed in three high complexity hospitals in Medellín, Colombia, between 2010 and 2015.
Out of 151 children, 74 (49%) had eosinophilic esophagitis, 35 (23.2%) had eosinophilic gastritis, 20 (13.2%), eosinophilic duodenitis, and 65 (43%) eosinophilic ileitis or colitis; 60.9% were males, and median age was 5 years; 66.9% had a history of allergic disease, and 78.8% had involvement of a single segment of the gastrointestinal tract. Main symptoms were abdominal pain and vomiting. Maximum eosinophil count per high power field (HPF) in the esophagus, stomach, duodenum, ileum and colon was 34, 21, 42, 45 and 60, respectively. Peripheral eosinophilia was more common in patients with esophageal and stomach involvement. The most sensitizing foods were egg, milk, shrimp, wheat and chicken. Proton pump inhibitors, steroids or immunosuppressants, as well as food-exclusion diets were used.
EGID can compromise multiple segments, and its symptoms are unspecific; multidisciplinary management is required.
嗜酸性粒细胞性胃肠道疾病（EGID）并不常见。在哥伦比亚，尚无针对儿科人群的研究。
描述患有EGID的儿科人群的流行病学、临床和诊断特征。
对2010年至2015年间在哥伦比亚麦德林的三家高复杂性医院接受评估的0至12岁儿童进行观察性回顾研究。
151名儿童中，74名（49%）患有嗜酸性粒细胞性食管炎，35名（23.2%）患有嗜酸性粒细胞性胃炎，20名（13.2%）患有嗜酸性粒细胞性十二指肠炎，65名（43%）患有嗜酸性粒细胞性回肠炎或结肠炎；60.9%为男性，中位年龄为5岁；66.9%有过敏疾病史，78.8%累及胃肠道的单个节段。主要症状为腹痛和呕吐。食管、胃、十二指肠、回肠和结肠每高倍视野（HPF）的嗜酸性粒细胞最大计数分别为34、21、42、45和60。外周嗜酸性粒细胞增多在食管和胃受累的患者中更常见。最常见的致敏食物为鸡蛋、牛奶、虾、小麦和鸡肉。使用了质子泵抑制剂、类固醇或免疫抑制剂以及食物排除饮食。
EGID可累及多个节段，其症状不具有特异性；需要多学科管理。
