Department of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, South-1 West-16, Chuo-ku, Sapporo 060-8556, Japan.
Department of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, South-1 West-16, Chuo-ku, Sapporo 060-8556, Japan; Department of Microbiology, Sapporo Medical University School of Medicine, South-1 West-16, Chuo-ku, Sapporo 060-8556, Japan.
Vaccine. 2018 Aug 9;36(33):4968-4972. doi: 10.1016/j.vaccine.2018.06.062. Epub 2018 Jul 6.
Interstitial lung diseases (ILD) are severe respiratory diseases, and ILD patients are treated with corticosteroid and immunosuppressive agents. However, it is unclear whether these medications influence the response of pneumococcal vaccine.
We examined the immunogenicity of pneumococcal vaccines (PPSV23 and PCV13) in ILD patients undergoing immunosuppressive treatment.
ILD patients who were regularly followed at the outpatient clinic were enrolled. Sera were collected before and 4-8 weeks after vaccination. Serotype-specific immunoglobulin G (IgG) concentrations against pneumococcal serotype 19F were measured by ELISA.
IgG concentrations to serotype 19F were increased in all groups in response to the vaccine. Both PCV13 and PPSV23 induced IgG concentrations in patients immunized for the first time. Response rates for the ILD group were comparable with those for the ILD group undergoing corticosteroid therapy. Only idiopathic pulmonary fibrosis patients undergoing immunosuppressive therapy had a significantly lower response.
间质性肺疾病（ILD）是严重的呼吸系统疾病，ILD 患者接受皮质类固醇和免疫抑制剂治疗。然而，目前尚不清楚这些药物是否会影响肺炎球菌疫苗的反应。
我们研究了接受免疫抑制治疗的ILD 患者中肺炎球菌疫苗（PPSV23 和 PCV13）的免疫原性。
ILD 患者在门诊定期就诊，采集疫苗接种前和接种后 4-8 周的血清。通过 ELISA 法检测针对肺炎球菌血清型 19F 的血清型特异性 IgG 浓度。
所有组针对疫苗的血清型 19F IgG 浓度均增加。PCV13 和 PPSV23 均能诱导首次免疫接种的患者产生 IgG 浓度。ILD 组的反应率与接受皮质类固醇治疗的 ILD 组相当。只有接受免疫抑制治疗的特发性肺纤维化患者的反应明显较低。
