Mel'nik S Ia, Bakhmedova A A, Nedorezova T P, Iartseva I V, Zhukova O S
Bioorg Khim. 1985 Sep;11(9):1248-52.
Glycosylation of silylated 5-trimethylgermyluracil with 2-deoxy-3,5-di-O-p-toluyl-alpha-D-ribofuranosylchloride in dichloroethane in the presence of SnCl4 and subsequent deacylation led to anomeric 5-trimethylgermyl-2'-deoxyuridines. The alpha-nucleoside inhibits HSV-1 replication in vitro, blocks 2'-deoxyuridine incorporation into DNA of hepatoma 22A cells and incorporation of thymidine into DNA of cancer ovarian cells as well. Treatment with 125 mg/kg X 5 days of alpha-nucleoside fails to increase the life-span of mice with leukemia P388.
在四氯化锡存在下，使甲硅烷基化的5 - 三甲基锗基尿嘧啶与2 - 脱氧 - 3,5 - 二 - O - 对甲苯甲酰基 - α - D - 呋喃核糖基氯在二氯乙烷中进行糖基化反应，随后进行脱酰基反应，得到了异头物5 - 三甲基锗基 - 2'- 脱氧尿苷。α - 核苷在体外抑制单纯疱疹病毒1型（HSV - 1）的复制，阻止2'- 脱氧尿苷掺入肝癌22A细胞的DNA以及胸苷掺入卵巢癌细胞的DNA。用125 mg/kg的α - 核苷处理5天，未能延长患白血病P388小鼠的寿命。
