Reeves B R, Lawler S D, Casey G, Harris H
Br J Cancer. 1985 Nov;52(5):719-24. doi: 10.1038/bjc.1985.249.
A cytogenetic follow-up study of patients treated with chemotherapy for gestational trophoblastic tumours was undertaken. In some cases, high levels of chromosome damage were found to persist in lymphocytes for several years after completion of therapy. These results are compared with those found in similar studies of non-malignant and other malignant diseases. The relevance of these findings to the risk of subsequent chemotherapy-induced malignancy is discussed.
对接受化疗的妊娠滋养细胞肿瘤患者进行了细胞遗传学随访研究。在某些病例中，发现治疗结束后数年淋巴细胞中仍持续存在高水平的染色体损伤。将这些结果与在非恶性疾病和其他恶性疾病的类似研究中发现的结果进行了比较。讨论了这些发现与后续化疗诱导恶性肿瘤风险的相关性。
