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Glutamate concentration in the anterior cingulate cortex in alcohol dependence: association with alcohol withdrawal and exploration of contribution from glutamatergic candidate genes.酒精依赖患者前扣带回皮质中的谷氨酸浓度：与酒精戒断的关联及谷氨酸能候选基因贡献的探索。
Psychiatr Genet. 2018 Oct;28(5):94-95. doi: 10.1097/YPG.0000000000000202.
2
Craving in alcohol-dependent patients after detoxification is related to glutamatergic dysfunction in the nucleus accumbens and the anterior cingulate cortex.在戒断后的酒精依赖患者中，渴望与伏隔核和前扣带皮层中的谷氨酸能功能障碍有关。
Neuropsychopharmacology. 2013 Jul;38(8):1401-8. doi: 10.1038/npp.2013.45. Epub 2013 Feb 12.
3
MR spectroscopy in opiate maintenance therapy: association of glutamate with the number of previous withdrawals in the anterior cingulate cortex.磁共振波谱在阿片类药物维持治疗中的应用：前扣带回皮层谷氨酸与既往戒断次数的相关性。
Addict Biol. 2012 May;17(3):659-67. doi: 10.1111/j.1369-1600.2010.00290.x. Epub 2011 Feb 11.
4
Translational magnetic resonance spectroscopy reveals excessive central glutamate levels during alcohol withdrawal in humans and rats.转化磁共振波谱研究揭示人类和大鼠酒精戒断期间中枢谷氨酸水平升高。
Biol Psychiatry. 2012 Jun 1;71(11):1015-21. doi: 10.1016/j.biopsych.2011.07.034. Epub 2011 Sep 10.
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Impact of family history of alcoholism on glutamine/glutamate ratio in anterior cingulate cortex in substance-naïve adolescents.酗酒家族史对未接触过成瘾物质的青少年前扣带回皮质中谷氨酰胺/谷氨酸比值的影响。
Dev Cogn Neurosci. 2015 Dec;16:147-154. doi: 10.1016/j.dcn.2015.04.005. Epub 2015 Apr 23.
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Anterior Cingulate Glutamate Is Reduced by Acamprosate Treatment in Patients With Alcohol Dependence.在酒精依赖患者中，阿坎酸治疗可降低前扣带回谷氨酸水平。
J Clin Psychopharmacol. 2016 Dec;36(6):669-674. doi: 10.1097/JCP.0000000000000590.
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Associations Between Recent Heavy Drinking and Dorsal Anterior Cingulate N-Acetylaspartate and Glutamate Concentrations in Non-Treatment-Seeking Individuals with Alcohol Dependence.近期大量饮酒与酒精依赖但未寻求治疗个体的背侧前扣带回中N-乙酰天门冬氨酸和谷氨酸浓度之间的关联。
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Glutamatergic and neurometabolic alterations in chronic cocaine users measured with (1) H-magnetic resonance spectroscopy.使用（1）H磁共振波谱法测量慢性可卡因使用者的谷氨酸能和神经代谢改变。
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Effects of Gabapentin on Dorsal Anterior Cingulate Cortex GABA and Glutamate Levels and Their Associations With Abstinence in Alcohol Use Disorder: A Randomized Clinical Trial.加巴喷丁对酒精使用障碍患者背侧前扣带回皮质γ-氨基丁酸和谷氨酸水平的影响及其与戒酒的关联：一项随机临床试验
Am J Psychiatry. 2021 Sep 1;178(9):829-837. doi: 10.1176/appi.ajp.2021.20121757. Epub 2021 Jul 14.
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Negative Association Between MR-Spectroscopic Glutamate Markers and Gray Matter Volume After Alcohol Withdrawal in the Hippocampus: A Translational Study in Humans and Rats.磁共振波谱谷氨酸标志物与海马体酒精戒断后灰质体积之间的负相关：一项人类和大鼠的转化研究
Alcohol Clin Exp Res. 2017 Feb;41(2):323-333. doi: 10.1111/acer.13308. Epub 2017 Jan 18.

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1
Anterior cingulate cortex is necessary for spontaneous opioid withdrawal and withdrawal-induced hyperalgesia in male mice.前扣带皮层对于雄性小鼠的自发阿片类药物戒断和戒断引起的痛觉过敏是必需的。
Neuropsychopharmacology. 2021 Oct;46(11):1990-1999. doi: 10.1038/s41386-021-01118-y. Epub 2021 Aug 2.
2
Cortical Glutamate and GABA Changes During Early Abstinence in Alcohol Dependence and Their Associations With Benzodiazepine Medication.酒精依赖早期戒断期间皮质谷氨酸和γ-氨基丁酸的变化及其与苯二氮䓬类药物的关联
Front Psychiatry. 2021 Jul 5;12:656468. doi: 10.3389/fpsyt.2021.656468. eCollection 2021.
3
Cerebral Metabolites on the Descending Limb of Acute Alcohol: A Preliminary 1H MRS Study.急性酒精作用下行支脑代谢物：一项初步的 1H MRS 研究。
Alcohol Alcohol. 2019 Jan 9;54(5):487-496. doi: 10.1093/alcalc/agz062.
4
Neuroimaging in alcohol use disorder: From mouse to man.酒精使用障碍的神经影像学：从鼠到人。
J Neurosci Res. 2022 May;100(5):1140-1158. doi: 10.1002/jnr.24423. Epub 2019 Apr 22.

本文引用的文献

1
Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism.在超过 329000 人的关联分析中，确定了 116 个独立的影响神经质的变异。
Nat Genet. 2018 Jan;50(1):6-11. doi: 10.1038/s41588-017-0013-8. Epub 2017 Dec 18.
2
Translational magnetic resonance spectroscopy reveals excessive central glutamate levels during alcohol withdrawal in humans and rats.转化磁共振波谱研究揭示人类和大鼠酒精戒断期间中枢谷氨酸水平升高。
Biol Psychiatry. 2012 Jun 1;71(11):1015-21. doi: 10.1016/j.biopsych.2011.07.034. Epub 2011 Sep 10.
3
Effect of acamprosate on magnetic resonance spectroscopy measures of central glutamate in detoxified alcohol-dependent individuals: a randomized controlled experimental medicine study.阿坎酸对戒酒的酒精依赖个体中枢谷氨酸磁共振波谱测定的影响：一项随机对照实验医学研究。
Arch Gen Psychiatry. 2010 Oct;67(10):1069-77. doi: 10.1001/archgenpsychiatry.2010.125.
4
Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk and treatment response to acamprosate.参与性脑钠肽转录因子 GATA4 在酒精依赖、复发风险和乙酰谷酰胺治疗反应中的作用。
Pharmacogenomics J. 2011 Oct;11(5):368-74. doi: 10.1038/tpj.2010.51. Epub 2010 Jun 29.
5
Alteration of brain metabolites in young alcoholics without structural changes.无结构改变的年轻酗酒者脑代谢物的变化
Neuroreport. 2007 Sep 17;18(14):1511-4. doi: 10.1097/WNR.0b013e3282ef7625.

酒精依赖患者前扣带回皮质中的谷氨酸浓度：与酒精戒断的关联及谷氨酸能候选基因贡献的探索。

Glutamate concentration in the anterior cingulate cortex in alcohol dependence: association with alcohol withdrawal and exploration of contribution from glutamatergic candidate genes.

作者信息

Streit Fabian, Treutlein Jens, Frischknecht Ulrich, Hermann Derik, Mann Karl, Kiefer Falk, Sack Markus, Hall Alisha S M, Frank Josef, Witt Stephanie H, Foo Jerome C, Degenhardt Franziska, Heilmann-Heimbach Stefanie, Nöthen Markus M, Sommer Wolfgang H, Spanagel Rainer, Rietschel Marcella, Ende Gabriele

机构信息

Departments of Genetic Epidemiology in Psychiatry.

Addictive Behaviour and Addiction Medicine.

出版信息

Psychiatr Genet. 2018 Oct;28(5):94-95. doi: 10.1097/YPG.0000000000000202.

DOI:10.1097/YPG.0000000000000202
PMID:29985185
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6133199/
Abstract

Supplemental Digital Content is available in the text.

摘要

文本中提供了补充数字内容。