Blundell J E, Rogers P J, Hill A J
Brain Res Bull. 1985 Oct;15(4):371-6. doi: 10.1016/0361-9230(85)90004-8.
The study of experimentally induced anorexia poses a problem for investigations of the processes controlling food intake. Inhibition of food consumption may arise from a specific intervention in a physiological system controlling nutritional requirements or from non-specific changes leading to the suppression or contamination of behaviour. The present experiment used the analysis of the structure of behaviour to distinguish between normal anorexia (natural development of satiation) and pathological anorexia brought about by intestinal discomfort (injection of lithium chloride) or adulteration of food (quinine added to diet). The treatments produced marked changes in parameters of feeding and in the frequencies of behaviours associated with eating. Both lithium chloride and quinine treatments gave rise to a slow rate of eating accompanied by a disordered temporal sequence of eating, grooming and resting. This behavioural calibration of anorexia can contribute to the behavioural pharmacology of feeding by helping to diagnose drugs which facilitate normal processes of satiation and those which act via a non-specific disruption of behaviour.
对实验性诱导厌食症的研究给控制食物摄入过程的调查带来了一个问题。食物消耗的抑制可能源于对控制营养需求的生理系统的特定干预，或者源于导致行为抑制或干扰的非特异性变化。本实验通过对行为结构的分析，区分正常厌食症（饱腹感的自然发展）和由肠道不适（注射氯化锂）或食物掺假（在饮食中添加奎宁）引起的病理性厌食症。这些处理在进食参数以及与进食相关的行为频率上产生了显著变化。氯化锂和奎宁处理均导致进食速度减慢，同时伴随着进食、梳理毛发和休息的时间顺序紊乱。这种厌食症的行为校准有助于喂养行为药理学，通过帮助诊断促进正常饱腹感过程的药物以及那些通过非特异性行为干扰起作用的药物。
