Weiland E, Weiland F
Clin Exp Immunol. 1985 Oct;62(1):167-75.
A transmissible agent inducing autoantibody has been found in association with tumours induced in STU mice with the progressor strain of Moloney sarcoma virus (Mo-MSV). The activity of the agent detectable in serum from tumour-bearing hosts was expressed by development of autoantibody against Golgi-associated evolutionary conserved antigen (Weiland et al. 1984). This agent was tentatively designated 'AGIA', anti-Golgi inducing agent, on account of its most remarkable biological activity. Concomittant with autoantibodies were cytotoxic antibodies reactive with a Mo-MSV non-producer transformant (Sac). Both antibody activities were regularly detectable 2 weeks after inoculation of the agent. At that time the antibody containing serum possessed an infectivity titre of approximately 10(7.5) ID50/ml. Signs of illness were not observed during this period. The antibody-inducing agent was lost from progressor Mo-MSV transformants during their first passage in culture. Neither murine embryo fibroblasts nor murine tumour cells were permissive for propagation of the agent in vitro.
在感染莫洛尼肉瘤病毒（Mo-MSV）进展株的STU小鼠所诱发的肿瘤中，发现了一种可诱导自身抗体的传染性因子。在荷瘤宿主血清中可检测到的该因子活性，表现为针对高尔基体相关进化保守抗原的自身抗体的产生（韦兰等人，1984年）。由于其最为显著的生物学活性，该因子被暂定为“AGIA”，即抗高尔基体诱导因子。与自身抗体相伴的，还有与Mo-MSV非产生型转化体（Sac）发生反应的细胞毒性抗体。在接种该因子两周后，这两种抗体活性均可定期检测到。此时，含抗体血清的感染滴度约为10(7.5) ID50/ml。在此期间未观察到疾病迹象。抗体诱导因子在进展型Mo-MSV转化体的首次传代培养过程中丢失。小鼠胚胎成纤维细胞和小鼠肿瘤细胞在体外均不允许该因子增殖。
